Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 30 vom: 06. Juli, Seite e2100077
1. Verfasser:	Ximendes, Erving (VerfasserIn)
Weitere Verfasser:	Marin, Riccardo, Shen, Yingli, Ruiz, Diego, Gómez-Cerezo, Diego, Rodríguez-Sevilla, Paloma, Lifante, Jose, Viveros-Méndez, Perla X, Gámez, Francisco, García-Soriano, David, Salas, Gorka, Zalbidea, Carmen, Espinosa, Ana, Benayas, Antonio, García-Carrillo, Nuria, Cussó, Lorena, Desco, Manuel, Teran, Francisco J, Juárez, Beatriz H, Jaque, Daniel
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2021
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article in vivo imaging luminescence thermometry magnetic hyperthermia near-infrared fluorescence silver sulfide nanoparticles Contrast Media Fluorescent Dyes Nanocapsules Silver Compounds mehr... silver sulfide 9ZB10YHC1C

Beschreibung
Zusammenfassung:	© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH. Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. However, MNPs fail to provide real-time thermal feedback with the risk of unwanted overheating and impeding on-the-fly adjustment of the therapeutic parameters. Localization of MNPs within a tissue in an accurate, rapid, and cost-effective way represents another challenge for increasing the efficacy of MHT. In this work, MNPs are combined with state-of-the-art infrared luminescent nanothermometers (LNTh; Ag2 S nanoparticles) in a nanocapsule that simultaneously overcomes these limitations. The novel optomagnetic nanocapsule acts as multimodal contrast agents for different imaging techniques (magnetic resonance, photoacoustic and near-infrared fluorescence imaging, optical and X-ray computed tomography). Most crucially, these nanocapsules provide accurate (0.2 °C resolution) and real-time subcutaneous thermal feedback during in vivo MHT, also enabling the attainment of thermal maps of the area of interest. These findings are a milestone on the road toward controlled magnetothermal therapies with minimal side effects
Beschreibung:	Date Completed 05.01.2022 Date Revised 13.10.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202100077