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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202008123
|2 doi
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|a pubmed24n1481.xml
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|a eng
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|a Feng, Zhe
|e verfasserin
|4 aut
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|a Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally
|b Horizons in Future Clinical Nanomedicine
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Superb reliability and biocompatibility equip aggregation-induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA-BBT) dots with strong absorption and extremely high second near-infrared region (NIR-II) PLQY of 13.6% is designed, and a long-aliphatic-chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA-BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR-IIb), large-depth cerebral vasculature (beyond 600 µm) as well as real-time blood flow are monitored through a thinned skull, and noninvasive NIR-IIb imaging with rich high-spatial-frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA-BBT dots from the body is demonstrated, which provides influential evidence of biosafety
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|a Journal Article
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|a NIR-IIb
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|a aggregation-induced emission dots
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|a biologically excretable
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|a fluorescence imaging
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|a long aliphatic chain
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|a non-human primates
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|a Polyethylene Glycols
|2 NLM
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|a 3WJQ0SDW1A
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|a Fluorescent Dyes
|2 NLM
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|a Bai, Siyi
|e verfasserin
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|a Qi, Ji
|e verfasserin
|4 aut
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|a Sun, Chaowei
|e verfasserin
|4 aut
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|a Zhang, Yuhuang
|e verfasserin
|4 aut
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|a Yu, Xiaoming
|e verfasserin
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|a Ni, Huwei
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|a Wu, Di
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|a Fan, Xiaoxiao
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|a Xue, Dingwei
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|a Liu, Shunjie
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|a Chen, Ming
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|a Gong, Junyi
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|a Wei, Peifa
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|a He, Mubin
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|a Lam, Jacky W Y
|e verfasserin
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|a Li, Xinjian
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|a Tang, Ben Zhong
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|a Gao, Lixia
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|a Qian, Jun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 17 vom: 01. Apr., Seite e2008123
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:33
|g year:2021
|g number:17
|g day:01
|g month:04
|g pages:e2008123
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|u http://dx.doi.org/10.1002/adma.202008123
|3 Volltext
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