Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally Horizons in Future Clinical Nanomedicine

Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally : Horizons in Future Clinical Nanomedicine

© 2021 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 17 vom: 01. Apr., Seite e2008123
1. Verfasser: Feng, Zhe (VerfasserIn)
Weitere Verfasser: Bai, Siyi, Qi, Ji, Sun, Chaowei, Zhang, Yuhuang, Yu, Xiaoming, Ni, Huwei, Wu, Di, Fan, Xiaoxiao, Xue, Dingwei, Liu, Shunjie, Chen, Ming, Gong, Junyi, Wei, Peifa, He, Mubin, Lam, Jacky W Y, Li, Xinjian, Tang, Ben Zhong, Gao, Lixia, Qian, Jun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article NIR-IIb aggregation-induced emission dots biologically excretable fluorescence imaging long aliphatic chain non-human primates Polyethylene Glycols 3WJQ0SDW1A Fluorescent Dyes
Beschreibung
Zusammenfassung:© 2021 Wiley-VCH GmbH.
Superb reliability and biocompatibility equip aggregation-induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA-BBT) dots with strong absorption and extremely high second near-infrared region (NIR-II) PLQY of 13.6% is designed, and a long-aliphatic-chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA-BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR-IIb), large-depth cerebral vasculature (beyond 600 µm) as well as real-time blood flow are monitored through a thinned skull, and noninvasive NIR-IIb imaging with rich high-spatial-frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA-BBT dots from the body is demonstrated, which provides influential evidence of biosafety
Beschreibung:Date Completed 24.07.2024
Date Revised 24.07.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202008123