Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

© 2021 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 9 vom: 17. März, Seite e2006570
1. Verfasser: Zhang, Yue (VerfasserIn)
Weitere Verfasser: Khalique, Anila, Du, Xinchen, Gao, Zhanxia, Wu, Jin, Zhang, Xiangyun, Zhang, Ran, Sun, Zhiyuan, Liu, Qiqi, Xu, Zhelong, Midgley, Adam C, Wang, Lianyong, Yan, Xiyun, Zhuang, Jie, Kong, Deling, Huang, Xinglu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article de novo design mitochondria nanozymes protein scaffolds superoxide scavengers Amino Acids Free Radical Scavengers Hydrogels Manganese Compounds mehr... Oxides Superoxides 11062-77-4 Ferritins 9007-73-2 Catalase EC 1.11.1.6 Superoxide Dismutase EC 1.15.1.1 manganese dioxide TF219GU161
LEADER 01000naa a22002652 4500
001 NLM320427072
003 DE-627
005 20231225173547.0
007 cr uuu---uuuuu
008 231225s2021 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.202006570  |2 doi 
028 5 2 |a pubmed24n1068.xml 
035 |a (DE-627)NLM320427072 
035 |a (NLM)33480459 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Zhang, Yue  |e verfasserin  |4 aut 
245 1 0 |a Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers 
264 1 |c 2021 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 19.10.2021 
500 |a Date Revised 19.10.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2021 Wiley-VCH GmbH. 
520 |a Development of enzyme mimics for the scavenging of excessive mitochondrial superoxide (O2 •- ) can serve as an effective strategy in the treatment of many diseases. Here, protein reconstruction technology and nanotechnology is taken advantage of to biomimetically create an artificial hybrid nanozyme. These nanozymes consist of ferritin-heavy-chain-based protein as the enzyme scaffold and a metal nanoparticle core as the enzyme active center. This artificial cascade nanozyme possesses superoxide dismutase- and catalase-like activities and also targets mitochondria by overcoming multiple biological barriers. Using cardiac ischemia-reperfusion animal models, the protective advantages of the hybrid nanozymes are demonstrated in vivo during mitochondrial oxidative injury and in the recovery of heart functionality following infarction via systemic delivery and localized release from adhesive hydrogels (i.e., cardiac patch), respectively. This study illustrates a de novo design strategy in the development of enzyme mimics and provides a promising therapeutic option for alleviating oxidative damage in regenerative medicine 
650 4 |a Journal Article 
650 4 |a de novo design 
650 4 |a mitochondria 
650 4 |a nanozymes 
650 4 |a protein scaffolds 
650 4 |a superoxide scavengers 
650 7 |a Amino Acids  |2 NLM 
650 7 |a Free Radical Scavengers  |2 NLM 
650 7 |a Hydrogels  |2 NLM 
650 7 |a Manganese Compounds  |2 NLM 
650 7 |a Oxides  |2 NLM 
650 7 |a Superoxides  |2 NLM 
650 7 |a 11062-77-4  |2 NLM 
650 7 |a Ferritins  |2 NLM 
650 7 |a 9007-73-2  |2 NLM 
650 7 |a Catalase  |2 NLM 
650 7 |a EC 1.11.1.6  |2 NLM 
650 7 |a Superoxide Dismutase  |2 NLM 
650 7 |a EC 1.15.1.1  |2 NLM 
650 7 |a manganese dioxide  |2 NLM 
650 7 |a TF219GU161  |2 NLM 
700 1 |a Khalique, Anila  |e verfasserin  |4 aut 
700 1 |a Du, Xinchen  |e verfasserin  |4 aut 
700 1 |a Gao, Zhanxia  |e verfasserin  |4 aut 
700 1 |a Wu, Jin  |e verfasserin  |4 aut 
700 1 |a Zhang, Xiangyun  |e verfasserin  |4 aut 
700 1 |a Zhang, Ran  |e verfasserin  |4 aut 
700 1 |a Sun, Zhiyuan  |e verfasserin  |4 aut 
700 1 |a Liu, Qiqi  |e verfasserin  |4 aut 
700 1 |a Xu, Zhelong  |e verfasserin  |4 aut 
700 1 |a Midgley, Adam C  |e verfasserin  |4 aut 
700 1 |a Wang, Lianyong  |e verfasserin  |4 aut 
700 1 |a Yan, Xiyun  |e verfasserin  |4 aut 
700 1 |a Zhuang, Jie  |e verfasserin  |4 aut 
700 1 |a Kong, Deling  |e verfasserin  |4 aut 
700 1 |a Huang, Xinglu  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 33(2021), 9 vom: 17. März, Seite e2006570  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:33  |g year:2021  |g number:9  |g day:17  |g month:03  |g pages:e2006570 
856 4 0 |u http://dx.doi.org/10.1002/adma.202006570  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 33  |j 2021  |e 9  |b 17  |c 03  |h e2006570