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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1111/nph.17175
|2 doi
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|a pubmed24n1066.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Li, Ying
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Dual roles of the serine/arginine-rich splicing factor SR45a in promoting and interacting with nuclear cap-binding complex to modulate the salt-stress response in Arabidopsis
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.05.2021
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|a Date Revised 31.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation.
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|a Alternative splicing (AS) is emerging as a critical co-transcriptional regulation for plants in response to environmental stresses. Although multiple splicing factors have been linked to the salt-sensitive signaling network, the molecular mechanism remains unclear. We discovered that a conserved serine/arginine-rich (SR)-like protein, SR45a, as a component of the spliceosome, was involved in post-transcriptional regulation of salinity tolerance in Arabidopsis thaliana. Furthermore, SR45a was required for the AS and messenger RNA (mRNA) maturation of several salt-tolerance genes. Two alternatively spliced variants of SR45a were induced by salt stress, full-length SR45a-1a and the truncated isoform SR45a-1b, respectively. Lines with overexpression of SR45a-1a and SR45a-1b exhibited hypersensitive to salt stress. Our data indicated that SR45a directly interacted with the cap-binding complex (CBC) subunit cap-binding protein 20 (CBP20) which mediated salt-stress responses. Instead of binding to other spliceosome components, SR45a-1b promoted the association of SR45a-1a with CBP20, therefore mediating salt-stress signal transduction pathways. Additionally, the mutations in SR45a and CBP20 led to different salt-stress phenotypes. Together, these results provide the evidence that SR45a-CBP20 acts as a regulatory complex to regulate the plant response to salt stress, through a regulatory mechanism to fine-tune the splicing factors, especially in stressful conditions
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CBP20
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|a SR45a
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|a alternative splicing
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|a cap-binding complex
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|a post-transcriptional regulation
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|a salt stress
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|a serine/arginine-rich protein
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a RNA Splicing Factors
|2 NLM
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| 650 |
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|a RNA-Binding Proteins
|2 NLM
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| 650 |
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|a SR45a protein, Arabidopsis
|2 NLM
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| 650 |
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|a Serine
|2 NLM
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| 650 |
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|a 452VLY9402
|2 NLM
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|a Arginine
|2 NLM
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|a 94ZLA3W45F
|2 NLM
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| 700 |
1 |
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|a Guo, Qianhuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Peng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Jinguang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shizhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Guodong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Changai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Chengchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Kang
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 230(2021), 2 vom: 15. Apr., Seite 641-655
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:230
|g year:2021
|g number:2
|g day:15
|g month:04
|g pages:641-655
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|u http://dx.doi.org/10.1111/nph.17175
|3 Volltext
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