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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202003458
|2 doi
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|a pubmed24n1481.xml
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|a eng
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| 100 |
1 |
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|a Li, Jingchao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy
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| 264 |
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1 |
|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 Wiley-VCH GmbH.
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|a Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPNII R) with a photothermally triggered cargo release for second near-infrared (NIR-II) photothermal immunotherapy is reported here. SPNII R consists of a semiconducting polymer nanoparticle core as an NIR-II photothermal converter, which is doped with a toll-like receptor (TLR) agonist as an immunotherapy adjuvant and coated with a thermally responsive lipid shell. Upon NIR-II photoirradiation, SPNII R effectively generates heat not only to ablate tumors and induce immunogenic cell death (ICD), but also to melt the lipid layers for on-demand release of the TLR agonist. The combination of ICD and activation of TLR7/TLR8 enhances the maturation of dendritic cells, which amplifies anti-tumor immune responses. Thus, a single treatment of SPNII R-mediated NIR-II photothermal immunotherapy effectively inhibits growth of both primary and distant tumors and eliminates lung metastasis in a murine mouse model. This study thus provides a remote-controlled smart delivery system to synergize photomedicine with immunotherapy for enhanced cancer treatment
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|a Journal Article
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4 |
|a immunotherapies
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| 650 |
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4 |
|a organic nanoparticles
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| 650 |
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4 |
|a photothermal therapies
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| 650 |
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4 |
|a second near-infrared windows
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| 650 |
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7 |
|a Polymers
|2 NLM
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| 650 |
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7 |
|a Adjuvants, Immunologic
|2 NLM
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| 700 |
1 |
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|a Yu, Xiangrong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Yuyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Shasha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pu, Kanyi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 4 vom: 01. Jan., Seite e2003458
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:33
|g year:2021
|g number:4
|g day:01
|g month:01
|g pages:e2003458
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4 |
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|u http://dx.doi.org/10.1002/adma.202003458
|3 Volltext
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