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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c02229
|2 doi
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|a eng
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| 100 |
1 |
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|a Pritzl, Stefanie D
|e verfasserin
|4 aut
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|a Photolipid Bilayer Permeability is Controlled by Transient Pore Formation
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|c 2020
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 24.11.2020
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|a Date Revised 24.11.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Controlling the release or uptake of (bio-) molecules and drugs from liposomes is critically important for a range of applications in bioengineering, synthetic biology, and drug delivery. In this paper, we report how the reversible photoswitching of synthetic lipid bilayer membranes made from azobenzene-containing phosphatidylcholine (azo-PC) molecules (photolipids) leads to increased membrane permeability. We show that cell-sized, giant unilamellar vesicles (GUVs) prepared from photolipids display leakage of fluorescent dyes after irradiation with UV-A and visible light. Langmuir-Blodgett and patch-clamp measurements show that the permeability is the result of transient pore formation. By comparing the trans-to-cis and cis-to-trans isomerization process, we find that this pore formation is the result of area fluctuations and a change of the area cross-section between both photolipid isomers
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Urban, Patrick
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Prasselsperger, Alexander
|e verfasserin
|4 aut
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| 700 |
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|a Konrad, David B
|e verfasserin
|4 aut
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| 700 |
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|a Frank, James A
|e verfasserin
|4 aut
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| 700 |
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|a Trauner, Dirk
|e verfasserin
|4 aut
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|a Lohmüller, Theobald
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 36(2020), 45 vom: 17. Nov., Seite 13509-13515
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|x 1520-5827
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|g volume:36
|g year:2020
|g number:45
|g day:17
|g month:11
|g pages:13509-13515
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|u http://dx.doi.org/10.1021/acs.langmuir.0c02229
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