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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c02521
|2 doi
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|a pubmed24n1055.xml
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|a eng
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| 100 |
1 |
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|a Xu, Danyang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Transferred Photothermal to Photodynamic Therapy Based on the Marriage of Ultrathin Titanium Carbide and Up-Conversion Nanoparticles
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.06.2021
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|a Date Revised 21.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this research, upconversion nanoparticles (UCNPs) are used as a light conversion carrier, and their deep light source penetrability is closely combined with ultrathin two-dimensional (2D) Ti3C2Tx to explore the application efficiency of the complex in phototherapy. Due to the advantages of 2D Ti3C2Tx with its high absorbance to ultraviolet/visible light, rich atomic defects to load the drugs, and adjustable thinner structure, this 2D material is beneficially applied as the energy donor. UCNPs@Ti3C2Tx with a photothermal conversion efficiency of 20.7% is proven with the ability to generate reactive oxygen species under a 980 nm laser at the cellular level. Importantly, the main photothermal therapy method can be changed to a photodynamic therapy method due to the degradation of Ti3C2Tx to TiO2 under the oxygen-bearing environment. The in vivo experiment was continued to verify that UCNPs@Ti3C2Tx can kill tumor cells and inhibit tumor growth within a certain period. In addition, in vivo treatment with a combination of immunotherapy and phototherapy of UCNPsTi3C2Tx is carried out to achieve stronger tumor inhibition over the prolonged time points
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a titanium carbide
|2 NLM
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|a 12070-08-5
|2 NLM
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|a Titanium
|2 NLM
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|a D1JT611TNE
|2 NLM
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| 700 |
1 |
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|a Yang, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qu, Danyao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zhenni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Long
|e verfasserin
|4 aut
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|a Wu, Weiwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lv, Ruichan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 36(2020), 43 vom: 03. Nov., Seite 13060-13069
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:36
|g year:2020
|g number:43
|g day:03
|g month:11
|g pages:13060-13069
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|u http://dx.doi.org/10.1021/acs.langmuir.0c02521
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