γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion

γ-Secretase is a multisubunit complex that catalyzes intramembranous cleavage of transmembrane proteins. The lipid environment forms membrane microdomains that serve as spatio-temporal platforms for proteins to function properly. Despite substantial advances in the regulation of γ-secretase, the eff...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 36(2020), 23 vom: 16. Juni, Seite 6569-6579
1. Verfasser: Barros, Marilia (VerfasserIn)
Weitere Verfasser: Houlihan, William J, Paresi, Chelsea J, Brendel, Matthew, Rynearson, Kevin D, Lee, Chang-Wook, Prikhodko, Olga, Cregger, Cristina, Chang, Geoffrey, Wagner, Steven L, Gilchrist, M Lane, Li, Yue-Ming
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Amyloid beta-Protein Precursor Lipid Bilayers Membrane Lipids Amyloid Precursor Protein Secretases EC 3.4.-