|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM309346711 |
| 003 |
DE-627 |
| 005 |
20231225133718.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2020 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/nph.16629
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1031.xml
|
| 035 |
|
|
|a (DE-627)NLM309346711
|
| 035 |
|
|
|a (NLM)32350870
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Zhang, Yuzhou
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Directional auxin fluxes in plants by intramolecular domain-domain coevolution of PIN auxin transporters
|
| 264 |
|
1 |
|c 2020
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 14.05.2021
|
| 500 |
|
|
|a Date Revised 14.05.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a ©2020 The Authors. New Phytologist ©2020 New Phytologist Trust.
|
| 520 |
|
|
|a Morphogenesis and adaptive tropic growth in plants depend on gradients of the phytohormone auxin, mediated by the membrane-based PIN-FORMED (PIN) auxin transporters. PINs localize to a particular side of the plasma membrane (PM) or to the endoplasmic reticulum (ER) to directionally transport auxin and maintain intercellular and intracellular auxin homeostasis, respectively. However, the molecular cues that confer their diverse cellular localizations remain largely unknown. In this study, we systematically swapped the domains between ER- and PM-localized PIN proteins, as well as between apical and basal PM-localized PINs from Arabidopsis thaliana, to shed light on why PIN family members with similar topological structures reside at different membrane compartments within cells. Our results show that not only do the N- and C-terminal transmembrane domains (TMDs) and central hydrophilic loop contribute to their differential subcellular localizations and cellular polarity, but that the pairwise-matched N- and C-terminal TMDs resulting from intramolecular domain-domain coevolution are also crucial for their divergent patterns of localization. These findings illustrate the complexity of the evolutionary path of PIN proteins in acquiring their plethora of developmental functions and adaptive growth in plants
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a PIN auxin transporters
|
| 650 |
|
4 |
|a cellular polarity
|
| 650 |
|
4 |
|a directional auxin flow
|
| 650 |
|
4 |
|a domain swapping
|
| 650 |
|
4 |
|a domain-domain coevolution
|
| 650 |
|
4 |
|a subcellular membrane localization
|
| 650 |
|
7 |
|a Arabidopsis Proteins
|2 NLM
|
| 650 |
|
7 |
|a Indoleacetic Acids
|2 NLM
|
| 650 |
|
7 |
|a Membrane Transport Proteins
|2 NLM
|
| 650 |
|
7 |
|a Plant Growth Regulators
|2 NLM
|
| 700 |
1 |
|
|a Hartinger, Corinna
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Xiaojuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Friml, Jiří
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 227(2020), 5 vom: 15. Sept., Seite 1406-1416
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
|
| 773 |
1 |
8 |
|g volume:227
|g year:2020
|g number:5
|g day:15
|g month:09
|g pages:1406-1416
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/nph.16629
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 227
|j 2020
|e 5
|b 15
|c 09
|h 1406-1416
|