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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108374
|2 doi
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|a pubmed25n1024.xml
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|a (DE-627)NLM30734732X
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|a (NLM)32146336
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|a (PII)S1521-6616(19)30527-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Shao, Ming
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis
|b A meta-analysis
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.10.2020
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|a Date Revised 19.10.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a OBJECTIVES: The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17F gene polymorphism with ankylosing spondylitis (AS), osteoarthritis (OA) and rheumatoid arthritis (RA)
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|a METHODS: We searched Medline up to August 2019. The summary Odds Ratio (OR) with corresponding 95% confidence intervals (CIs) was calculated to evaluate the relationship between IL-17A and IL-17F gene polymorphism with genetic susceptibility of AS, OA and RA
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|a RESULTS: A total of 19 studies with 5298 cases and 5675 healthy controls were included. There were significant associations between rs2275913 G allele with OA, RA susceptibility (P < .05) but not AS. Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to AS and OA in Caucasian populations (P < .001) but not Mongolians. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < .05)
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|a CONCLUSION: IL-17F gene rs763780 C allele confers increased risk of inflammatory arthritis in Caucasians; IL-17A gene rs2275913 G allele are protective for OA susceptibility in Mongolians. More well-designed studies with larger sample size are needed to elucidate the role of IL-17A gene rs2275913 G allele in inflammatory arthritis, especially AS
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|a Journal Article
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|a Meta-Analysis
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|a Research Support, Non-U.S. Gov't
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|a Arthritis
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| 650 |
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|a Interleukin-17
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| 650 |
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|a Meta-analysis
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| 650 |
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|a Osteoarthritis
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| 650 |
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|a Polymorphism
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| 650 |
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|a IL17A protein, human
|2 NLM
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| 650 |
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|a IL17F protein, human
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 700 |
1 |
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|a Xu, Shanshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Jixiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yuting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Xing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guan, Shiyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Shengqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shuai, Zongwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Faming
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 213(2020) vom: 27. Apr., Seite 108374
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:213
|g year:2020
|g day:27
|g month:04
|g pages:108374
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108374
|3 Volltext
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