Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis A meta-analysis

Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis : A meta-analysis

Copyright © 2020 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 213(2020) vom: 27. Apr., Seite 108374
1. Verfasser: Shao, Ming (VerfasserIn)
Weitere Verfasser: Xu, Shanshan, Yang, Hui, Xu, Wei, Deng, Jixiang, Chen, Yuting, Gao, Xing, Guan, Shiyang, Xu, Shengqian, Shuai, Zongwen, Pan, Faming
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Arthritis Interleukin-17 Meta-analysis Osteoarthritis Polymorphism IL17A protein, human IL17F protein, human
Beschreibung
Zusammenfassung:Copyright © 2020 Elsevier Inc. All rights reserved.
OBJECTIVES: The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17F gene polymorphism with ankylosing spondylitis (AS), osteoarthritis (OA) and rheumatoid arthritis (RA)
METHODS: We searched Medline up to August 2019. The summary Odds Ratio (OR) with corresponding 95% confidence intervals (CIs) was calculated to evaluate the relationship between IL-17A and IL-17F gene polymorphism with genetic susceptibility of AS, OA and RA
RESULTS: A total of 19 studies with 5298 cases and 5675 healthy controls were included. There were significant associations between rs2275913 G allele with OA, RA susceptibility (P < .05) but not AS. Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to AS and OA in Caucasian populations (P < .001) but not Mongolians. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < .05)
CONCLUSION: IL-17F gene rs763780 C allele confers increased risk of inflammatory arthritis in Caucasians; IL-17A gene rs2275913 G allele are protective for OA susceptibility in Mongolians. More well-designed studies with larger sample size are needed to elucidate the role of IL-17A gene rs2275913 G allele in inflammatory arthritis, especially AS
Beschreibung:Date Completed 19.10.2020
Date Revised 19.10.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2020.108374