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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108327
|2 doi
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|a eng
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| 100 |
1 |
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|a Schnabel, Anja
|e verfasserin
|4 aut
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| 245 |
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|a High-dose intravenous methylprednisolone in juvenile non-infectious uveitis
|b A retrospective analysis
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 04.08.2020
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|a Date Revised 04.08.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results
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|a Journal Article
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|a Childhood
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|a Corticosteroid
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| 650 |
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|a Juvenile
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| 650 |
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|a Methylprednisolone
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| 650 |
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|a Ocular inflammation
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|a Treatment
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| 650 |
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|a Uveitis
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| 650 |
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|a Adrenal Cortex Hormones
|2 NLM
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|a Anti-Inflammatory Agents
|2 NLM
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|a Methylprednisolone
|2 NLM
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| 650 |
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|a X4W7ZR7023
|2 NLM
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| 700 |
1 |
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|a Unger, Elisabeth
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brück, Normi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Berner, Reinhard
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Range, Ursula
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holl-Wieden, Annette
|e verfasserin
|4 aut
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| 700 |
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|a Morbach, Henner
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Leszczynska, Anna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bau, Viktoria
|e verfasserin
|4 aut
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| 700 |
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|a Hedrich, Christian M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 211(2020) vom: 15. Feb., Seite 108327
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|g volume:211
|g year:2020
|g day:15
|g month:02
|g pages:108327
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|u http://dx.doi.org/10.1016/j.clim.2019.108327
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