High-dose intravenous methylprednisolone in juvenile non-infectious uveitis A retrospective analysis

High-dose intravenous methylprednisolone in juvenile non-infectious uveitis : A retrospective analysis

Copyright © 2019 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 211(2020) vom: 15. Feb., Seite 108327
1. Verfasser: Schnabel, Anja (VerfasserIn)
Weitere Verfasser: Unger, Elisabeth, Brück, Normi, Berner, Reinhard, Range, Ursula, Holl-Wieden, Annette, Morbach, Henner, Leszczynska, Anna, Bau, Viktoria, Hedrich, Christian M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Childhood Corticosteroid Juvenile Methylprednisolone Ocular inflammation Treatment Uveitis Adrenal Cortex Hormones Anti-Inflammatory Agents X4W7ZR7023
Beschreibung
Zusammenfassung:Copyright © 2019 Elsevier Inc. All rights reserved.
Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results
Beschreibung:Date Completed 04.08.2020
Date Revised 04.08.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2019.108327