Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children

Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children

Copyright © 2019 Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 211(2020) vom: 01. Feb., Seite 108319
Auteur principal: Vecchione, Andrea (Auteur)
Autres auteurs: Di Fonte, Roberta, Gerosa, Jolanda, Jofra, Tatiana, Cicalese, Maria Pia, Napoleone, Vincenzo, Ippolito, Elio, Galvani, Giuseppe, Ragogna, Francesca, Stabilini, Angela, Bianconi, Eleonora, Grogan, Pauline, Bonura, Clara, Bonfanti, Riccardo, Frontino, Giulio, Nano, Rita, Melzi, Raffaela, De Pellegrin, Maurizio, Laurenzi, Andrea, Meschi, Franco, Barera, Graziano, Rigamonti, Andrea, Indirli, Rita, Bosi, Emanuele, Piemonti, Lorenzo, Aiuti, Alessandro, Battaglia, Manuela, Fousteri, Georgia
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't AAb-negative AAb-positive Autoantibodies (AAb) CXCL13 Follicular Treg cells PD-1 Regulatory T cells (Treg) plus... Tfh cells Type 1 diabetes (T1D) Autoantibodies CXCR5 protein, human FOXP3 protein, human Forkhead Transcription Factors PDCD1 protein, human Programmed Cell Death 1 Receptor Receptors, CXCR5
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100 1 |a Vecchione, Andrea  |e verfasserin  |4 aut 
245 1 0 |a Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children 
264 1 |c 2020 
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500 |a Date Completed 04.08.2020 
500 |a Date Revised 20.08.2020 
500 |a published: Print-Electronic 
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520 |a Copyright © 2019 Elsevier Inc. All rights reserved. 
520 |a Autoantibodies (AAbs) are a hallmark of Type 1 diabetes (T1D). Alterations in the frequency and phenotype of follicular helper (Tfh) T cells have been previously documented in patients with type 1 diabetes (T1D), but the contribution of follicular regulatory T (Treg) cells, which are responsible for suppressing AAb development, is less clear. Here, we investigated the frequency and activation status of follicular (CXCR5+) and conventional (CXCR5-) Treg cells in the blood of children with new-onset T1D, and children with risk for developing T1D (AAb-positive) and compared them to AAb-negative controls. Blood follicular and conventional Treg cells were higher in frequency in children with new onset T1D, but expressed reduced amounts of PD-1 as compared to AAb-negative children. Interestingly, the proportion of circulating FOXP3+ Tregs expressing PD-1 was also reduced in AAb-positive at-risk children as compared to AAb-negative controls, suggesting its potential use as a biomarker of disease progression. Follicular Treg cells were reduced in frequency in the spleens of prediabetic NOD mice as they became older and turned diabetic. Interestingly, PD-1 expression declined also on circulating follicular and conventional Treg cells in prediabetic NOD mice as they aged. Together, these findings show that the frequency of circulating follicular and conventional Treg cells and their levels of PD-1 change with disease progression in children at-risk for developing T1D and in NOD mice 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a AAb-negative 
650 4 |a AAb-positive 
650 4 |a Autoantibodies (AAb) 
650 4 |a CXCL13 
650 4 |a Follicular Treg cells 
650 4 |a PD-1 
650 4 |a Regulatory T cells (Treg) 
650 4 |a Tfh cells 
650 4 |a Type 1 diabetes (T1D) 
650 7 |a Autoantibodies  |2 NLM 
650 7 |a CXCR5 protein, human  |2 NLM 
650 7 |a FOXP3 protein, human  |2 NLM 
650 7 |a Forkhead Transcription Factors  |2 NLM 
650 7 |a PDCD1 protein, human  |2 NLM 
650 7 |a Programmed Cell Death 1 Receptor  |2 NLM 
650 7 |a Receptors, CXCR5  |2 NLM 
700 1 |a Di Fonte, Roberta  |e verfasserin  |4 aut 
700 1 |a Gerosa, Jolanda  |e verfasserin  |4 aut 
700 1 |a Jofra, Tatiana  |e verfasserin  |4 aut 
700 1 |a Cicalese, Maria Pia  |e verfasserin  |4 aut 
700 1 |a Napoleone, Vincenzo  |e verfasserin  |4 aut 
700 1 |a Ippolito, Elio  |e verfasserin  |4 aut 
700 1 |a Galvani, Giuseppe  |e verfasserin  |4 aut 
700 1 |a Ragogna, Francesca  |e verfasserin  |4 aut 
700 1 |a Stabilini, Angela  |e verfasserin  |4 aut 
700 1 |a Bianconi, Eleonora  |e verfasserin  |4 aut 
700 1 |a Grogan, Pauline  |e verfasserin  |4 aut 
700 1 |a Bonura, Clara  |e verfasserin  |4 aut 
700 1 |a Bonfanti, Riccardo  |e verfasserin  |4 aut 
700 1 |a Frontino, Giulio  |e verfasserin  |4 aut 
700 1 |a Nano, Rita  |e verfasserin  |4 aut 
700 1 |a Melzi, Raffaela  |e verfasserin  |4 aut 
700 1 |a De Pellegrin, Maurizio  |e verfasserin  |4 aut 
700 1 |a Laurenzi, Andrea  |e verfasserin  |4 aut 
700 1 |a Meschi, Franco  |e verfasserin  |4 aut 
700 1 |a Barera, Graziano  |e verfasserin  |4 aut 
700 1 |a Rigamonti, Andrea  |e verfasserin  |4 aut 
700 1 |a Indirli, Rita  |e verfasserin  |4 aut 
700 1 |a Bosi, Emanuele  |e verfasserin  |4 aut 
700 1 |a Piemonti, Lorenzo  |e verfasserin  |4 aut 
700 1 |a Aiuti, Alessandro  |e verfasserin  |4 aut 
700 1 |a Battaglia, Manuela  |e verfasserin  |4 aut 
700 1 |a Fousteri, Georgia  |e verfasserin  |4 aut 
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