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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1111/nph.16285
|2 doi
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|a pubmed24n1008.xml
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|a (DE-627)NLM302622160
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|a (NLM)31657467
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Cheng, Guangyuan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Remorin interacting with PCaP1 impairs Turnip mosaic virus intercellular movement but is antagonised by VPg
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.05.2021
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|a Date Revised 31.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2019 The Authors. New Phytologist © 2019 New Phytologist Trust.
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|a Group 1 Remorins (REMs) are extensively involved in virus trafficking through plasmodesmata (PD). However, their roles in Potyvirus cell-to-cell movement are not known. The plasma membrane (PM)-associated Ca2+ binding protein 1 (PCaP1) interacts with the P3N-PIPO of Turnip mosaic virus (TuMV) and is required for TuMV cell-to-cell movement, but the underlying mechanism remains elusive. The mutant plants with overexpression or knockout of REM1.2 were used to investigate its role in TuMV cell-to-cell movement. Arabidopsis thaliana complementary mutants of pcap1 were used to investigate the role of PCaP1 in TuMV cell-to-cell movement. Yeast-two-hybrid, bimolecular fluorescence complementation, co-immunoprecipitation and RT-qPCR assays were employed to investigate the underlying molecular mechanism. The results show that TuMV-P3N-PIPO recruits PCaP1 to PD and the actin filament-severing activity of PCaP1 is required for TuMV intercellular movement. REM1.2 negatively regulates the cell-to-cell movement of TuMV via competition with PCaP1 for binding actin filaments. As a counteractive response, TuMV mediates REM1.2 degradation via both 26S ubiquitin-proteasome and autophagy pathways through the interaction of VPg with REM1.2 to establish systemic infection in Arabidopsis. This work unveils the actin cytoskeleton and PM nanodomain-associated molecular events underlying the cell-to-cell movement of potyviruses
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Potyvirus
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| 650 |
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4 |
|a Remorin
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| 650 |
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4 |
|a VPg
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| 650 |
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4 |
|a actin filaments
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| 650 |
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4 |
|a cell-to-cell movement
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| 650 |
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7 |
|a Plant Proteins
|2 NLM
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| 650 |
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|a Viral Proteins
|2 NLM
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| 650 |
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|a remorin
|2 NLM
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| 700 |
1 |
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|a Yang, Zongtao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jisen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Jingsheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 225(2020), 5 vom: 01. März, Seite 2122-2139
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
8 |
|g volume:225
|g year:2020
|g number:5
|g day:01
|g month:03
|g pages:2122-2139
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| 856 |
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|u http://dx.doi.org/10.1111/nph.16285
|3 Volltext
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|d 225
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|h 2122-2139
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