pH Responsiveness of Hexosomes and Cubosomes for Combined Delivery of Brucea javanica Oil and Doxorubicin

We report pH-responsive liquid crystalline lipid nanoparticles, which are dual-loaded by Brucea javanica oil (BJO) and doxorubicin hydrochloride (DOX) and display a pH-induced inverted hexagonal (pH = 7.4) to cubic (pH = 6.8) to emulsified microemulsion (pH = 5.3) phase transition with a therapeutic...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 35(2019), 45 vom: 12. Nov., Seite 14532-14542
1. Verfasser: Li, Yawen (VerfasserIn)
Weitere Verfasser: Angelova, Angelina, Hu, Fangzhou, Garamus, Vasil M, Peng, Changjun, Li, Na, Liu, Jianwen, Liu, Dan, Zou, Aihua
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibiotics, Antineoplastic Drug Carriers Lipids Plant Oils Doxorubicin 80168379AG
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520 |a We report pH-responsive liquid crystalline lipid nanoparticles, which are dual-loaded by Brucea javanica oil (BJO) and doxorubicin hydrochloride (DOX) and display a pH-induced inverted hexagonal (pH = 7.4) to cubic (pH = 6.8) to emulsified microemulsion (pH = 5.3) phase transition with a therapeutic application in cancer inhibition. BJO is a traditional herbal medicine that strongly inhibits the proliferation and metastasis of various cancers. Doxorubicin is an antitumor drug, which prevents DNA replication and hampers protein synthesis through intercalation between the base pairs of the DNA helices. Its dose-dependent cardiotoxicity imposes the need for safe delivery carriers. Here, pH-induced changes in the structural and interfacial properties of designed multicomponent drug delivery (monoolein-oleic acid-BJO-DOX) systems are determined by synchrotron small-angle X-ray scattering and the Langmuir film balance technique. The nanocarrier assemblies display good physical stability in the studied pH range and adequate particle sizes and ζ-potentials. Their interaction with model lipid membrane interfaces is enhanced under acidic pH conditions, which mimic the microenvironment around tumor cells. In vitro cytotoxicity and apoptosis studies with BJO-DOX dual-loaded pH-switchable liquid crystalline nanoparticles are performed on the human breast cancer Michigan Cancer Foundation-7 (MCF-7) cell line and MCF-7 cells with doxorubicin resistance (MCF-7/DOX), respectively. The obtained pH-sensitive nanomedicines exhibit enhanced antitumor efficacy. The performed preliminary studies suggest a potential reversal of the resistance of the MCF-7/DOX cells to DOX. These results highlight the necessity for further understanding the link between the established pH-dependent drug release profiles of the nanocarriers and the role of their pH-switchable inverted hexagonal, bicontinuous cubic, and emulsified microemulsion inner organizations for therapeutic outcomes 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Antibiotics, Antineoplastic  |2 NLM 
650 7 |a Drug Carriers  |2 NLM 
650 7 |a Lipids  |2 NLM 
650 7 |a Plant Oils  |2 NLM 
650 7 |a Doxorubicin  |2 NLM 
650 7 |a 80168379AG  |2 NLM 
700 1 |a Angelova, Angelina  |e verfasserin  |4 aut 
700 1 |a Hu, Fangzhou  |e verfasserin  |4 aut 
700 1 |a Garamus, Vasil M  |e verfasserin  |4 aut 
700 1 |a Peng, Changjun  |e verfasserin  |4 aut 
700 1 |a Li, Na  |e verfasserin  |4 aut 
700 1 |a Liu, Jianwen  |e verfasserin  |4 aut 
700 1 |a Liu, Dan  |e verfasserin  |4 aut 
700 1 |a Zou, Aihua  |e verfasserin  |4 aut 
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773 1 8 |g volume:35  |g year:2019  |g number:45  |g day:12  |g month:11  |g pages:14532-14542 
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