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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b01939
|2 doi
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|a pubmed24n1002.xml
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|a (DE-627)NLM300786034
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|a (NLM)31469284
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Mason, McKensie L
|e verfasserin
|4 aut
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| 245 |
1 |
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|a pH-Controlled Chiral Packing and Self-Assembly of a Coumarin Tetrapeptide
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.08.2020
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|a Date Revised 17.08.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A coumarin-tetrapeptide conjugate, EFEK(DAC)-NH2 (1), is reported to undergo a pH-dependent interconversion between nanotubes and nanoribbons. An examination of zeta potential measurements, circular dichroism (CD) spectra, and microscopy imaging (transmission electron microscopy and atomic force microscopy) identified three different self-assembly regimes based on pH: (1) pH 2-5, positively charged, left-handed helical nanotubes; (2) pH 6-8, negatively charged, right-handed helical nanoribbons; and (3) pH ≥ 9.0, a monomeric/disassembled peptide. The nanotubes exhibited uniform diameters of 41 ± 5 nm and wall thicknesses of 4.8 ± 0.8 nm, whereas the nanoribbons existed as either flat or twisted sheets ranging in width from 11 to 60 nm with heights of 8 ± 1 nm. The UV-vis and CD spectra of the most common antiparallel, β-sheet conformation of 1-dimer were simulated at the B3LYP/def2svpd level of theory in implicit water. These studies indicated that the transition from nanotubes to nanoribbons was coupled to an M → P helical inversion of the coumarin packing orientation, respectively, within the nanostructures. The assembly process was driven by β-sheet aggregation and π-π interactions, leading to the formation of nanoribbons, which progressively wound into helical ribbons and laterally grew into smooth nanotubes as the pH decreased
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Coumarins
|2 NLM
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|a Nanotubes, Carbon
|2 NLM
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|a Oligopeptides
|2 NLM
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|a Lalisse, Remy F
|e verfasserin
|4 aut
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|a Finnegan, Tyler J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hadad, Christopher M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Modarelli, David A
|e verfasserin
|4 aut
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| 700 |
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|a Parquette, Jon R
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 38 vom: 24. Sept., Seite 12460-12468
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:35
|g year:2019
|g number:38
|g day:24
|g month:09
|g pages:12460-12468
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|u http://dx.doi.org/10.1021/acs.langmuir.9b01939
|3 Volltext
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