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NLM297359983 |
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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b01190
|2 doi
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|a pubmed24n0991.xml
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|a eng
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| 100 |
1 |
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|a Zhang, Huifang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a One-Pot Synthesis of Chicken-Feather-Keratin-Based Prodrug Nanoparticles with High Drug Content for Tumor Intracellular DOX Delivery
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|c 2019
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|a Text
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|a ƒaComputermedien
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|a Date Completed 17.08.2020
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|a Date Revised 17.08.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a pH/reduction dual-triggered chicken-feather-keratin-based prodrug nanoparticles (C-PK/- SS-Hy-D NPs) were designed via a facile one-pot oxidation coupling reaction between the thiol-functional acid-labile prodrug M-Hy-D and the PEGylated keratin (PK) graft copolymer, for tumor intracellular doxorubicin (DOX) delivery. Due to the encapsulation of the pH and the reduction of the dual-responsive small prodrug D-Hy- SS-Hy-D, a high drug content of 45.8% was obtained in the proposed prodrug nanoparticles. They exhibited excellent pH and reduction of dual-triggered drug release, with cumulative drug release of 88.6% within 51 h in the simulated tumor intracellular microenvironment, while the premature drug leakage was only 13.7% in the simulated normal physiological medium. The in vitro experiments revealed the enhanced antitumor efficacy of the C-PK/- SS-Hy-D NPs than the free DOX at a higher dosage of >10 μg/mL
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|a Journal Article
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|a Prodrugs
|2 NLM
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|a Keratins
|2 NLM
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| 650 |
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|a 68238-35-7
|2 NLM
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| 650 |
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|a Doxorubicin
|2 NLM
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| 650 |
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|a 80168379AG
|2 NLM
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| 700 |
1 |
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|a Liu, Peng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 24 vom: 18. Juni, Seite 8007-8014
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|x 1520-5827
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|g volume:35
|g year:2019
|g number:24
|g day:18
|g month:06
|g pages:8007-8014
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|u http://dx.doi.org/10.1021/acs.langmuir.9b01190
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