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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201900545
|2 doi
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|a pubmed24n0988.xml
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|a eng
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| 100 |
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|a Zhu, Wei
|e verfasserin
|4 aut
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|a SupraCells
|b Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.11.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionalities could revolutionize fields like cell-based sensing and create diverse new cellular phenotypes. Herein, the concept of "SupraCells," which are living mammalian cells encapsulated and protected within functional modular nanoparticle-based exoskeletons, is introduced. Exoskeletons are generated within seconds through immediate interparticle and cell/particle complexation that abolishes the macropinocytotic and endocytotic nanoparticle internalization pathways that occur without complexation. SupraCell formation is shown to be generalizable to wide classes of nanoparticles and various types of cells. It induces a spore-like state, wherein cells do not replicate or spread on surfaces but are endowed with extremophile properties, for example, resistance to osmotic stress, reactive oxygen species, pH, and UV exposure, along with abiotic properties like magnetism, conductivity, and multifluorescence. Upon decomplexation cells return to their normal replicative states. SupraCells represent a new class of living hybrid materials with a broad range of functionalities
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|a Journal Article
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|a artificial exoskeleton
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|a biomimetic encapsulation
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|a mammalian cell
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|a multifunctions
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|a nanoparticles
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|a Biocompatible Materials
|2 NLM
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|a Guo, Jimin
|e verfasserin
|4 aut
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|a Amini, Shahrouz
|e verfasserin
|4 aut
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|a Ju, Yi
|e verfasserin
|4 aut
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|a Agola, Jacob Ongudi
|e verfasserin
|4 aut
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|a Zimpel, Andreas
|e verfasserin
|4 aut
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|a Shang, Jin
|e verfasserin
|4 aut
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|a Noureddine, Achraf
|e verfasserin
|4 aut
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|a Caruso, Frank
|e verfasserin
|4 aut
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|a Wuttke, Stefan
|e verfasserin
|4 aut
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|a Croissant, Jonas G
|e verfasserin
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|a Brinker, C Jeffrey
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 25 vom: 30. Juni, Seite e1900545
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|g year:2019
|g number:25
|g day:30
|g month:06
|g pages:e1900545
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|u http://dx.doi.org/10.1002/adma.201900545
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