SupraCells Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons

SupraCells : Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 25 vom: 30. Juni, Seite e1900545
1. Verfasser: Zhu, Wei (VerfasserIn)
Weitere Verfasser: Guo, Jimin, Amini, Shahrouz, Ju, Yi, Agola, Jacob Ongudi, Zimpel, Andreas, Shang, Jin, Noureddine, Achraf, Caruso, Frank, Wuttke, Stefan, Croissant, Jonas G, Brinker, C Jeffrey
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article artificial exoskeleton biomimetic encapsulation mammalian cell multifunctions nanoparticles Biocompatible Materials
Beschreibung
Zusammenfassung:© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionalities could revolutionize fields like cell-based sensing and create diverse new cellular phenotypes. Herein, the concept of "SupraCells," which are living mammalian cells encapsulated and protected within functional modular nanoparticle-based exoskeletons, is introduced. Exoskeletons are generated within seconds through immediate interparticle and cell/particle complexation that abolishes the macropinocytotic and endocytotic nanoparticle internalization pathways that occur without complexation. SupraCell formation is shown to be generalizable to wide classes of nanoparticles and various types of cells. It induces a spore-like state, wherein cells do not replicate or spread on surfaces but are endowed with extremophile properties, for example, resistance to osmotic stress, reactive oxygen species, pH, and UV exposure, along with abiotic properties like magnetism, conductivity, and multifluorescence. Upon decomplexation cells return to their normal replicative states. SupraCells represent a new class of living hybrid materials with a broad range of functionalities
Beschreibung:Date Completed 21.11.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201900545