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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erz191
|2 doi
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|a pubmed24n0987.xml
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|a (DE-627)NLM296404608
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|a (NLM)31020325
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Alvarez Prado, Santiago
|e verfasserin
|4 aut
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| 245 |
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|a To clean or not to clean phenotypic datasets for outlier plants in genetic analyses?
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 20.07.2020
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|a Date Revised 20.07.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a Based on case studies, we discuss the extent to which genome-wide association studies (GWAS) are affected by outlier plants, i.e. those deviating from the expected distribution on a multi-criteria basis. Using a raw dataset consisting of daily measurements of leaf area, biomass, and plant height for thousands of plants, we tested three different cleaning methods for their effects on genetic analyses. No-cleaning resulted in the highest number of dubious quantitative trait loci, especially at loci with highly unbalanced allelic frequencies. A trade-off was identified between the risk of false-positives (with no-cleaning and/or a low threshold for minor allele frequency) and the risk of missing interesting rare alleles. Cleaning can lower the risk of the latter by making it possible to choose a higher threshold in GWAS
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Allele frequency
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| 650 |
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4 |
|a genetic analysis
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| 650 |
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4 |
|a outliers
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| 650 |
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4 |
|a phenomics
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| 650 |
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|a quantitative trait loci
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| 650 |
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|a statistical analysis
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| 650 |
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|a Plant Proteins
|2 NLM
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| 700 |
1 |
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|a Sanchez, Isabelle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cabrera-Bosquet, Llorenç
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grau, Antonin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Welcker, Claude
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tardieu, François
|e verfasserin
|4 aut
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| 700 |
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|a Hilgert, Nadine
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 70(2019), 15 vom: 07. Aug., Seite 3693-3698
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:70
|g year:2019
|g number:15
|g day:07
|g month:08
|g pages:3693-3698
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|u http://dx.doi.org/10.1093/jxb/erz191
|3 Volltext
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