Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 201(2019) vom: 20. Apr., Seite 55-60
Auteur principal: Nabatanzi, Rose (Auteur)
Autres auteurs: Bayigga, Lois, Cose, Stephen, Rowland-Jones, Sarah, Canderan, Glenda, Joloba, Moses, Nakanjako, Damalie
Format: Article en ligne
Langue:English
Publié: 2019
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't 107a Antiretroviral therapy Granzyme-B Interferon gamma NK Cytolytic function NK cell activation NK cell dysfunction NK degranulation plus... NKG2D NKp46 Natural killer cells Sub-Saharan Africa Anti-Retroviral Agents Antigens, CD Antigens, Differentiation, T-Lymphocyte CD69 antigen KLRK1 protein, human Lectins, C-Type Lysosomal-Associated Membrane Protein 1 NCR1 protein, human NK Cell Lectin-Like Receptor Subfamily K Natural Cytotoxicity Triggering Receptor 1 Granzymes EC 3.4.21.-
Description
Résumé:Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
BACKGROUND: We examined NK cell phenotypes and functions after seven years of ART and undetectable viral loads (<50 copies/ml) with restored CD4 T-cell counts (≥500 cells/μl) and age-matched healthy-HIV-uninfected individuals from the same community
METHODS: Using flow-cytometry, NK cell phenotypes were described using lineage markers (CD56+/-CD16+/-). NK cell activation was determined by expression of activation receptors (NKG2D, NKp44 and NKp46) and activation marker CD69. NK cell function was determined by CD107a, granzyme-b, and IFN-gamma production
RESULTS: CD56 dim and CD56 bright NK cells were lower among ART-treated-HIV-infected than among age-matched-HIV-negative individuals; p = 0.0016 and p = 0.05 respectively. Production of CD107a (P = 0.004) and Granzyme-B (P = 0.005) was lower among ART-treated-HIV-infected relative to the healthy-HIV-uninfected individuals. NKG2D and NKp46 were lower, while CD69 expression was higher among ART-treated-HIV-infected than healthy-HIV-uninfected individuals
CONCLUSION: NK cell activation and dysfunction persisted despite seven years of suppressive ART with "normalization" of peripheral CD4 counts
Description:Date Completed 21.01.2020
Date Revised 07.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2019.02.010