Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 201(2019) vom: 20. Apr., Seite 55-60
1. Verfasser: Nabatanzi, Rose (VerfasserIn)
Weitere Verfasser: Bayigga, Lois, Cose, Stephen, Rowland-Jones, Sarah, Canderan, Glenda, Joloba, Moses, Nakanjako, Damalie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't 107a Antiretroviral therapy Granzyme-B Interferon gamma NK Cytolytic function NK cell activation NK cell dysfunction NK degranulation mehr... NKG2D NKp46 Natural killer cells Sub-Saharan Africa Anti-Retroviral Agents Antigens, CD Antigens, Differentiation, T-Lymphocyte CD69 antigen KLRK1 protein, human Lectins, C-Type Lysosomal-Associated Membrane Protein 1 NCR1 protein, human NK Cell Lectin-Like Receptor Subfamily K Natural Cytotoxicity Triggering Receptor 1 Granzymes EC 3.4.21.-
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100 1 |a Nabatanzi, Rose  |e verfasserin  |4 aut 
245 1 0 |a Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort 
264 1 |c 2019 
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500 |a Date Completed 21.01.2020 
500 |a Date Revised 07.12.2022 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. 
520 |a BACKGROUND: We examined NK cell phenotypes and functions after seven years of ART and undetectable viral loads (<50 copies/ml) with restored CD4 T-cell counts (≥500 cells/μl) and age-matched healthy-HIV-uninfected individuals from the same community 
520 |a METHODS: Using flow-cytometry, NK cell phenotypes were described using lineage markers (CD56+/-CD16+/-). NK cell activation was determined by expression of activation receptors (NKG2D, NKp44 and NKp46) and activation marker CD69. NK cell function was determined by CD107a, granzyme-b, and IFN-gamma production 
520 |a RESULTS: CD56 dim and CD56 bright NK cells were lower among ART-treated-HIV-infected than among age-matched-HIV-negative individuals; p = 0.0016 and p = 0.05 respectively. Production of CD107a (P = 0.004) and Granzyme-B (P = 0.005) was lower among ART-treated-HIV-infected relative to the healthy-HIV-uninfected individuals. NKG2D and NKp46 were lower, while CD69 expression was higher among ART-treated-HIV-infected than healthy-HIV-uninfected individuals 
520 |a CONCLUSION: NK cell activation and dysfunction persisted despite seven years of suppressive ART with "normalization" of peripheral CD4 counts 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a 107a 
650 4 |a Antiretroviral therapy 
650 4 |a Granzyme-B 
650 4 |a Interferon gamma 
650 4 |a NK Cytolytic function 
650 4 |a NK cell activation 
650 4 |a NK cell dysfunction 
650 4 |a NK degranulation 
650 4 |a NKG2D 
650 4 |a NKp46 
650 4 |a Natural killer cells 
650 4 |a Sub-Saharan Africa 
650 7 |a Anti-Retroviral Agents  |2 NLM 
650 7 |a Antigens, CD  |2 NLM 
650 7 |a Antigens, Differentiation, T-Lymphocyte  |2 NLM 
650 7 |a CD69 antigen  |2 NLM 
650 7 |a KLRK1 protein, human  |2 NLM 
650 7 |a Lectins, C-Type  |2 NLM 
650 7 |a Lysosomal-Associated Membrane Protein 1  |2 NLM 
650 7 |a NCR1 protein, human  |2 NLM 
650 7 |a NK Cell Lectin-Like Receptor Subfamily K  |2 NLM 
650 7 |a Natural Cytotoxicity Triggering Receptor 1  |2 NLM 
650 7 |a Granzymes  |2 NLM 
650 7 |a EC 3.4.21.-  |2 NLM 
700 1 |a Bayigga, Lois  |e verfasserin  |4 aut 
700 1 |a Cose, Stephen  |e verfasserin  |4 aut 
700 1 |a Rowland-Jones, Sarah  |e verfasserin  |4 aut 
700 1 |a Canderan, Glenda  |e verfasserin  |4 aut 
700 1 |a Joloba, Moses  |e verfasserin  |4 aut 
700 1 |a Nakanjako, Damalie  |e verfasserin  |4 aut 
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773 1 8 |g volume:201  |g year:2019  |g day:20  |g month:04  |g pages:55-60 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2019.02.010  |3 Volltext 
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