Towards synchrotron phase-contrast lung imaging in patients - a proof-of-concept study on porcine lungs in a human-scale chest phantom

Towards synchrotron phase-contrast lung imaging in patients - a proof-of-concept study on porcine lungs in a human-scale chest phantom

In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a c...

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Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 25(2018), Pt 6 vom: 01. Nov., Seite 1827-1832
1. Verfasser: Wagner, Willi L (VerfasserIn)
Weitere Verfasser: Wuennemann, Felix, Pacilé, Serena, Albers, Jonas, Arfelli, Fulvia, Dreossi, Diego, Biederer, Jürgen, Konietzke, Philip, Stiller, Wolfram, Wielpütz, Mark O, Accardo, Agostino, Confalonieri, Marco, Cova, Maria, Lotz, Joachim, Alves, Frauke, Kauczor, Hans Ulrich, Tromba, Giuliana, Dullin, Christian
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article high-resolution porcine lung imaging phase retrieval preclinical chest phantom propagation based imaging synchrotron radiation
Beschreibung
Zusammenfassung:In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a chest phantom with ventilated fresh porcine lungs. Local areas of interest were imaged with a pixel size of 100 µm, yielding a high-resolution depiction of anatomical hallmarks of healthy lungs and artificial lung nodules. Details like fine spiculations into surrounding alveolar spaces were shown on a micrometre scale. Minor differences in artificial lung nodule density were detected by phase retrieval. Since we only applied a fraction of the X-ray dose used for clinical high-resolution CT scans, it is believed that this approach may become applicable to the detailed assessment of focal lung lesions in patients in the future
Beschreibung:Date Completed 21.12.2018
Date Revised 21.12.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1600-5775
DOI:10.1107/S1600577518013401