Quantitative Fundus Autofluorescence in Non-Neovascular Age-Related Macular Degeneration
Copyright 2018, SLACK Incorporated.
| Publié dans: | Ophthalmic surgery, lasers & imaging retina. - 2013. - 49(2018), 10 vom: 15. Okt., Seite S34-S42 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2018
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| Accès à la collection: | Ophthalmic surgery, lasers & imaging retina |
| Sujets: | Journal Article Multicenter Study Research Support, Non-U.S. Gov't |
| Résumé: | Copyright 2018, SLACK Incorporated. BACKGROUND AND OBJECTIVE: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD) PATIENTS AND METHODS: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) RESULTS: The patients included in this study had a mean age of 83.9 years, and 35.7% patients were men. Mean qAF was higher in control participants than in all patients with AMD (P < .001). According to non-neovascular AMD phenotype, mean qAF levels were significantly lower in eyes with subretinal drusenoid deposits than in control eyes (P < .05). The lowest mean qAF was in patients with geographic atrophy CONCLUSION: Quantitative fundus autofluorescence of non-neovascular AMD decreases from normal to early to late AMD, suggesting that loss of lipofuscin fluorophores, not increase, signifies AMD progression. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:S34-S42.] |
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| Description: | Date Completed 20.03.2019 Date Revised 20.03.2019 published: Print Citation Status MEDLINE |
| ISSN: | 2325-8179 |
| DOI: | 10.3928/23258160-20180814-06 |