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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.09.014
|2 doi
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|a pubmed24n0964.xml
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|a (PII)S1521-6616(18)30120-7
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|a DE-627
|b ger
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|e rakwb
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|a eng
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| 100 |
1 |
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|a van den Bossche, Wouter B L
|e verfasserin
|4 aut
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| 245 |
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|a Flow cytometric assessment of leukocyte kinetics for the monitoring of tissue damage
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.10.2019
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|a Date Revised 07.10.2019
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2020 Apr;213:108344. - PMID 31964597
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|a Citation Status MEDLINE
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|a Copyright © 2018. Published by Elsevier Inc.
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|a Leukocyte populations quickly respond to tissue damage, but most leukocyte kinetic studies are not based on multiparameter flow cytometry. We systematically investigated several blood leukocyte populations after controlled tissue damage. 48 patients were assigned to either an anterior or posterolateral total hip arthroplasty. Peripheral blood was collected pre-operatively and at 2 h, 24 h, 48 h, 2 and 6 weeks postoperatively and assessed by flow cytometry for absolute counts of multiple leukocyte populations using standardized EuroFlow protocols. Absolute counts of leukocyte subsets differed significantly between consecutive time points. Neutrophils increased instantly after surgery, while most leukocyte subsets initially decreased, followed by increasing cell counts until 48 h. At two weeks all leukocyte counts were restored to pre-operative counts. Immune cell kinetics upon acute tissue damage exhibit reproducible patterns, which differ between the leukocyte subsets and with "opposite kinetics" among monocyte subsets. Flow cytometric leukocyte monitoring can be used to minimally invasively monitor tissue damage
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Flow cytometry and multiparameter analysis
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|a Immune monitoring
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|a Leukocytes
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|a Tissue damage
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|a Rykov, Kyrill
|e verfasserin
|4 aut
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|a Teodosio, Cristina
|e verfasserin
|4 aut
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| 700 |
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|a Ten Have, Bas L E F
|e verfasserin
|4 aut
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|a Knobben, Bas A S
|e verfasserin
|4 aut
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| 700 |
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|a Sietsma, Maurits S
|e verfasserin
|4 aut
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| 700 |
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|a Josiassen, Karin
|e verfasserin
|4 aut
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| 700 |
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|a de Bruin-Versteeg, Sandra
|e verfasserin
|4 aut
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| 700 |
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|a Orfao, Alberto
|e verfasserin
|4 aut
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| 700 |
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|a van Dongen, Jacques J M
|e verfasserin
|4 aut
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| 700 |
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|a van Raay, Jos J A M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 197(2018) vom: 15. Dez., Seite 224-230
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|g pages:224-230
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|u http://dx.doi.org/10.1016/j.clim.2018.09.014
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