Biophysical Mechanisms of Membrane-Thickness-Dependent MscL Gating : An All-Atom Molecular Dynamics Study

The bacterial mechanosensitive channel, MscL, is activated by membrane tension, acting as a safety valve to prevent cell lysis against hypotonic challenge. It has been established that its activation threshold decreases with membrane thickness, while the underlying mechanism remains to be solved. We...

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Publié dans:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 35(2019), 23 vom: 11. Juni, Seite 7432-7442
Auteur principal:	Katsuta, Hiroki (Auteur)
Autres auteurs:	Sawada, Yasuyuki, Sokabe, Masahiro
Format:	Article en ligne
Langue:	English
Publié:	2019
Accès à la collection:	Langmuir : the ACS journal of surfaces and colloids
Sujets:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Escherichia coli Proteins Ion Channels MscL protein, E coli