Anticancer Agent Edelfosine Exhibits a High Affinity for Cholesterol and Disorganizes Liquid-Ordered Membrane Structures
Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glycerol, it possesses two hydrophobic substituents of very different lengths. We showed that edelfosine destabilizes liquid-ordered membranes formed by either 1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholi...
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Détails bibliographiques
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 34(2018), 28 vom: 17. Juli, Seite 8333-8346
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| Auteur principal: |
Ausili, Alessio
(Auteur) |
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| Autres auteurs: |
Martínez-Valera, Pablo,
Torrecillas, Alejandro,
Gómez-Murcia, Victoria,
de Godos, Ana M,
Corbalán-García, Senena,
Teruel, José A,
Gómez Fernández, Juan C |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2018
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids
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| Sujets: | Journal Article
Research Support, Non-U.S. Gov't
Antineoplastic Agents
Lipid Bilayers
Phospholipid Ethers
edelfosine
1Y6SNA8L5S
Cholesterol
97C5T2UQ7J |
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