Anticancer Agent Edelfosine Exhibits a High Affinity for Cholesterol and Disorganizes Liquid-Ordered Membrane Structures

Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glycerol, it possesses two hydrophobic substituents of very different lengths. We showed that edelfosine destabilizes liquid-ordered membranes formed by either 1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholi...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1999. - 34(2018), 28 vom: 17. Juli, Seite 8333-8346
1. Verfasser:	Ausili, Alessio (VerfasserIn)
Weitere Verfasser:	Martínez-Valera, Pablo, Torrecillas, Alejandro, Gómez-Murcia, Victoria, de Godos, Ana M, Corbalán-García, Senena, Teruel, José A, Gómez Fernández, Juan C
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2018
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antineoplastic Agents Lipid Bilayers Phospholipid Ethers edelfosine 1Y6SNA8L5S Cholesterol 97C5T2UQ7J