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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201800242
|2 doi
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|a pubmed25n1500.xml
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|a eng
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| 100 |
1 |
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|a Miri, Amir K
|e verfasserin
|4 aut
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|a Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 06.03.2019
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|a Date Revised 18.07.2025
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|a published: Print-Electronic
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|a ErratumIn: Adv Mater. 2025 Jul 17:e12660. doi: 10.1002/adma.202512660.. - PMID 40677019
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a A stereolithography-based bioprinting platform for multimaterial fabrication of heterogeneous hydrogel constructs is presented. Dynamic patterning by a digital micromirror device, synchronized by a moving stage and a microfluidic device containing four on/off pneumatic valves, is used to create 3D constructs. The novel microfluidic device is capable of fast switching between different (cell-loaded) hydrogel bioinks, to achieve layer-by-layer multimaterial bioprinting. Compared to conventional stereolithography-based bioprinters, the system provides the unique advantage of multimaterial fabrication capability at high spatial resolution. To demonstrate the multimaterial capacity of this system, a variety of hydrogel constructs are generated, including those based on poly(ethylene glycol) diacrylate (PEGDA) and gelatin methacryloyl (GelMA). The biocompatibility of this system is validated by introducing cell-laden GelMA into the microfluidic device and fabricating cellularized constructs. A pattern of a PEGDA frame and three different concentrations of GelMA, loaded with vascular endothelial growth factor, are further assessed for its neovascularization potential in a rat model. The proposed system provides a robust platform for bioprinting of high-fidelity multimaterial microstructures on demand for applications in tissue engineering, regenerative medicine, and biosensing, which are otherwise not readily achievable at high speed with conventional stereolithographic biofabrication platforms
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|a Journal Article
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|a bioprinting
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|a digital light prototyping
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|a digital micromirror devices
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|a microfluidics
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|a multimaterials
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|a Vascular Endothelial Growth Factor A
|2 NLM
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|a Hydrogel, Polyethylene Glycol Dimethacrylate
|2 NLM
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|a 25852-47-5
|2 NLM
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| 700 |
1 |
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|a Nieto, Daniel
|e verfasserin
|4 aut
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|a Iglesias, Luis
|e verfasserin
|4 aut
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|a Goodarzi Hosseinabadi, Hossein
|e verfasserin
|4 aut
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|a Maharjan, Sushila
|e verfasserin
|4 aut
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|a Ruiz-Esparza, Guillermo U
|e verfasserin
|4 aut
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|a Khoshakhlagh, Parastoo
|e verfasserin
|4 aut
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|a Manbachi, Amir
|e verfasserin
|4 aut
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|a Dokmeci, Mehmet Remzi
|e verfasserin
|4 aut
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|a Chen, Shaochen
|e verfasserin
|4 aut
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|a Shin, Su Ryon
|e verfasserin
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|a Zhang, Yu Shrike
|e verfasserin
|4 aut
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|a Khademhosseini, Ali
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 27 vom: 30. Juli, Seite e1800242
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:30
|g year:2018
|g number:27
|g day:30
|g month:07
|g pages:e1800242
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|u http://dx.doi.org/10.1002/adma.201800242
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