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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201705605
|2 doi
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|a pubmed24n0943.xml
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|a eng
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| 100 |
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|a Lin, Yu-Jung
|e verfasserin
|4 aut
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|a In Situ Self-Assembling Micellar Depots that Can Actively Trap and Passively Release NO with Long-Lasting Activity to Reverse Osteoporosis
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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| 500 |
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|a Date Completed 07.03.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Treatment with exogenous nitric oxide (NO) donors is regarded as being effective against osteoporosis. However, NO has a short half-life, limiting its clinical usefulness. To overcome this limitation, an injectable microparticle (MP) system is developed that consists of phase-change materials capric acid (CA) and octadecane, and encapsulates a NO donor. The therapeutic efficacy of the MPs is evaluated in ovariectomized (OVX) rats with osteoporosis. Upon subcutaneous administration, the MPs undergo a phase transition, leaching out the NO donor and generating NO bubbles that are instantly covered by a layer of tightly packed CA surfactant molecules, forming micellar depots. The in situ self-assembling micellar depots can actively protect the NO bubbles, prolonging their half-life, while the entrapped NO may passively diffuse through the micellar depots over time, performing a long-lasting therapeutic function, reversing the OVX-induced osteoporosis. It is possible to use the concept of in situ self-assembling micellar depots developed herein to expand the therapeutic effect of NO in its diverse range of clinical applications
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|a Journal Article
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|a bubble generation
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|a capric acid
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|a micellar depot
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|a nitric oxide
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|a osteoporosis
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|a Micelles
|2 NLM
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|a Nitric Oxide
|2 NLM
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| 650 |
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7 |
|a 31C4KY9ESH
|2 NLM
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| 700 |
1 |
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|a Chen, Chun-Chieh
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| 700 |
1 |
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|a Chi, Nai-Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nguyen, Trang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Hung-Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nguyen, Dang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Po-Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sung, Hsing-Wen
|e verfasserin
|4 aut
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| 773 |
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 30(2018), 22 vom: 17. Mai, Seite e1705605
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|u http://dx.doi.org/10.1002/adma.201705605
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