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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201707389
|2 doi
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|a pubmed24n0939.xml
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|a eng
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| 100 |
1 |
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|a Peng, Liuqi
|e verfasserin
|4 aut
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|a Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics
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|c 2018
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 06.02.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a 2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd3+ -doped monolayered-double-hydroxide (MLDH) nanosheets are prepared via a facile bottom-up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99.67%. This is, as far as it is known, the highest LC level at nearly 100% of EE among previously reported 2D drug delivery systems so far. Interestingly, the as-prepared DOX&ICG/MLDH composite material shows both pH-controlled and near-infrared-irradiation-induced DOX release, which holds a promise in stimulated drug release. An in vivo dual-mode imaging, including near-infrared fluorescence and magnetic resonance imaging, enables a noninvasive visualization of distribution profiles at the tumor site. In addition, in vitro and in vivo therapeutic evaluations demonstrate an excellent trimode synergetic anticancer activity and superior biocompatibility of DOX&ICG/MLDH. Therefore, MLDH nanosheets provide new perspectives in the design of multifunctional nanomedicine, which shows promising applications in controlled drug delivery and cancer theranostics
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|a Journal Article
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|a 2D nanomaterials
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|a cancer theranostics
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|a drug loading
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|a layered double hydroxides
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|a monolayer nanosheets
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|a Doxorubicin
|2 NLM
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|a 80168379AG
|2 NLM
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| 700 |
1 |
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|a Mei, Xuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Jun
|e verfasserin
|4 aut
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| 700 |
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|a Xu, Jiekun
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Weiku
|e verfasserin
|4 aut
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| 700 |
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|a Liang, Ruizheng
|e verfasserin
|4 aut
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| 700 |
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|a Wei, Min
|e verfasserin
|4 aut
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| 700 |
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|a Evans, David G
|e verfasserin
|4 aut
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| 700 |
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|a Duan, Xue
|e verfasserin
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
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|g 30(2018), 16 vom: 05. Apr., Seite e1707389
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|u http://dx.doi.org/10.1002/adma.201707389
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