Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impai...
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Bibliographische Detailangaben
| Veröffentlicht in: | Neural plasticity. - 1998. - 2018(2018) vom: 17., Seite 4196961
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| 1. Verfasser: |
Collo, Ginetta
(VerfasserIn) |
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| Weitere Verfasser: |
Cavalleri, Laura,
Bono, Federica,
Mora, Cristina,
Fedele, Stefania,
Invernizzi, Roberto William,
Gennarelli, Massimo,
Piovani, Giovanna,
Kunath, Tilo,
Millan, Mark J,
Merlo Pich, Emilio,
Spano, PierFranco |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2018
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| Zugriff auf das übergeordnete Werk: | Neural plasticity
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Antiparkinson Agents
Benzothiazoles
Brain-Derived Neurotrophic Factor
Indoles
ropinirole
030PYR8953
BDNF protein, human
7171WSG8A2
mehr...
Pramipexole
83619PEU5T
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1 |
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