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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1111/nph.15007
|2 doi
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|a pubmed25n0936.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Sopeña-Torres, Sara
|e verfasserin
|4 aut
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|a YODA MAP3K kinase regulates plant immune responses conferring broad-spectrum disease resistance
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 19.09.2019
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|a Date Revised 18.03.2022
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|a published: Print-Electronic
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|a GENBANK: GSE79026, GSE95609, PXD006988
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|a Citation Status MEDLINE
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|a © 2018 Universidad Politécnica de Madrid (UPM) New Phytologist © 2018 New Phytologist Trust.
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|a Mitogen-activated protein kinases (MAPKs) cascades play essential roles in plants by transducing developmental cues and environmental signals into cellular responses. Among the latter are microbe-associated molecular patterns perceived by pattern recognition receptors (PRRs), which trigger immunity. We found that YODA (YDA) - a MAPK kinase kinase regulating several Arabidopsis developmental processes, like stomatal patterning - also modulates immune responses. Resistance to pathogens is compromised in yda alleles, whereas plants expressing the constitutively active YDA (CA-YDA) protein show broad-spectrum resistance to fungi, bacteria, and oomycetes with different colonization modes. YDA functions in the same pathway as ERECTA (ER) Receptor-Like Kinase, regulating both immunity and stomatal patterning. ER-YDA-mediated immune responses act in parallel to canonical disease resistance pathways regulated by phytohormones and PRRs. CA-YDA plants exhibit altered cell-wall integrity and constitutively express defense-associated genes, including some encoding putative small secreted peptides and PRRs whose impairment resulted in enhanced susceptibility phenotypes. CA-YDA plants show strong reprogramming of their phosphoproteome, which contains protein targets distinct from described MAPKs substrates. Our results suggest that, in addition to stomata development, the ER-YDA pathway regulates an immune surveillance system conferring broad-spectrum disease resistance that is distinct from the canonical pathways mediated by described PRRs and defense hormones
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a ERECTA
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|a cell wall
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|a mitogen-activated protein kinases (MAPKs)
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|a pattern recognition receptor (PRR)
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|a plant immunity
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|a receptor-like kinase (RLK)
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|a stomata
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|a Arabidopsis Proteins
|2 NLM
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|a Pathogen-Associated Molecular Pattern Molecules
|2 NLM
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|a Flagellin
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|a 12777-81-0
|2 NLM
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|a MAP Kinase Kinase Kinases
|2 NLM
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|a EC 2.7.11.25
|2 NLM
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|a YODA protein, Arabidopsis
|2 NLM
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|a EC 2.7.11.25
|2 NLM
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|a Jordá, Lucía
|e verfasserin
|4 aut
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|a Sánchez-Rodríguez, Clara
|e verfasserin
|4 aut
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|a Miedes, Eva
|e verfasserin
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|a Escudero, Viviana
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|a Swami, Sanjay
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|a López, Gemma
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|a Piślewska-Bednarek, Mariola
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|a Lassowskat, Ines
|e verfasserin
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|a Lee, Justin
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|a Gu, Yangnan
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|a Haigis, Sabine
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|a Alexander, Danny
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|a Pattathil, Sivakumar
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|a Muñoz-Barrios, Antonio
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|a Bednarek, Pawel
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|a Somerville, Shauna
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|a Schulze-Lefert, Paul
|e verfasserin
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|a Hahn, Michael G
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|a Scheel, Dierk
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|a Molina, Antonio
|e verfasserin
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|i Enthalten in
|t The New phytologist
|d 1984
|g 218(2018), 2 vom: 15. Apr., Seite 661-680
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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|g volume:218
|g year:2018
|g number:2
|g day:15
|g month:04
|g pages:661-680
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|u http://dx.doi.org/10.1111/nph.15007
|3 Volltext
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