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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.01.006
|2 doi
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|a pubmed24n0935.xml
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|a (DE-627)NLM28055754X
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|a (NLM)29395846
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|a (PII)S1521-6616(17)30780-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Flinn, A M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Thymopoiesis following HSCT; a retrospective review comparing interventions for aGVHD in a pediatric cohort
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| 264 |
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.08.2019
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|a Date Revised 27.08.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Acute graft-versus-host disease (aGVHD) complicates allogeneic hematopoietic stem cell transplantation (HSCT), and is treated with topical and/or systemic corticosteroids. Systemic corticosteroids and aGVHD damage thymic tissue. We compared thymopoietic effect of topical steroid therapy, corticosteroids and extracorporeal photopheresis (ECP) in 102 pediatric allogeneic HSCT patients. We categorized patients into 4 groups: - no aGVHD, aGVHD treated with topical or systemic steroid, or ECP. Naïve CD4+CD45RA+CD27+ T-lymphocyte values at 3, 6, 9, 12months post-HSCT were recorded: for ECP patients, values were recorded at 3, 6, 9, 12months during ECP. Differences were compared using the Kruskal-Wallis test. 41 patients had no aGVHD, 23 had aGVHD treated topically or systemically (25), 13 received ECP. Rate of thymopoiesis was significantly different between all groups at all time-points post-transplant (p=0.002, p<0.001, p<0.001, p=0.001 respectively). Even mild aGVHD impairs thymopoiesis. Worst recovery was in ECP patients. Earlier institution of ECP may speed thymic recovery
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Acute graft-versus-host-disease
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| 650 |
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4 |
|a Corticosteroids
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| 650 |
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4 |
|a Extracorporeal photopheresis
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| 650 |
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4 |
|a Hematopoietic stem cell transplant
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| 650 |
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4 |
|a Immunoreconstitution
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| 650 |
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4 |
|a Thymopoiesis
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| 650 |
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|a Adrenal Cortex Hormones
|2 NLM
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| 650 |
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|a Immunosuppressive Agents
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 650 |
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7 |
|a Leukocyte Common Antigens
|2 NLM
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| 650 |
|
7 |
|a EC 3.1.3.48
|2 NLM
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| 700 |
1 |
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|a Roberts, C F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Slatter, M A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Skinner, R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Robson, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lawrence, J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guest, J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gennery, A R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 193(2018) vom: 30. Aug., Seite 33-37
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:193
|g year:2018
|g day:30
|g month:08
|g pages:33-37
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2018.01.006
|3 Volltext
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