Thymopoiesis following HSCT; a retrospective review comparing interventions for aGVHD in a pediatric cohort

Thymopoiesis following HSCT; a retrospective review comparing interventions for aGVHD in a pediatric cohort

Copyright © 2018 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 193(2018) vom: 30. Aug., Seite 33-37
1. Verfasser: Flinn, A M (VerfasserIn)
Weitere Verfasser: Roberts, C F, Slatter, M A, Skinner, R, Robson, H, Lawrence, J, Guest, J, Gennery, A R
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Acute graft-versus-host-disease Corticosteroids Extracorporeal photopheresis Hematopoietic stem cell transplant Immunoreconstitution Thymopoiesis Adrenal Cortex Hormones Immunosuppressive Agents mehr... Tumor Necrosis Factor Receptor Superfamily, Member 7 Leukocyte Common Antigens EC 3.1.3.48
Beschreibung
Zusammenfassung:Copyright © 2018 Elsevier Inc. All rights reserved.
Acute graft-versus-host disease (aGVHD) complicates allogeneic hematopoietic stem cell transplantation (HSCT), and is treated with topical and/or systemic corticosteroids. Systemic corticosteroids and aGVHD damage thymic tissue. We compared thymopoietic effect of topical steroid therapy, corticosteroids and extracorporeal photopheresis (ECP) in 102 pediatric allogeneic HSCT patients. We categorized patients into 4 groups: - no aGVHD, aGVHD treated with topical or systemic steroid, or ECP. Naïve CD4+CD45RA+CD27+ T-lymphocyte values at 3, 6, 9, 12months post-HSCT were recorded: for ECP patients, values were recorded at 3, 6, 9, 12months during ECP. Differences were compared using the Kruskal-Wallis test. 41 patients had no aGVHD, 23 had aGVHD treated topically or systemically (25), 13 received ECP. Rate of thymopoiesis was significantly different between all groups at all time-points post-transplant (p=0.002, p<0.001, p<0.001, p=0.001 respectively). Even mild aGVHD impairs thymopoiesis. Worst recovery was in ECP patients. Earlier institution of ECP may speed thymic recovery
Beschreibung:Date Completed 27.08.2019
Date Revised 27.08.2019
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2018.01.006