Vital ex vivo tissue labeling and pathology-guided micropunching to characterize cellular heterogeneity in the tissue microenvironment

Cellular heterogeneity within the tissue microenvironment may underlie chemotherapeutic resistance and response, enabling tumor evolution; however, this heterogeneity it is difficult to characterize. Here, we present a new approach-pathology-guided micropunching (PGM)-that enables identification and...

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Détails bibliographiques
Publié dans:BioTechniques. - 1991. - 64(2018), 1 vom: 01. Jan., Seite 13-19
Auteur principal: Johnson, Brian P (Auteur)
Autres auteurs: Vitek, Ross A, Geiger, Peter G, Huang, Wei, Jarrard, David F, Lang, Joshua M, Beebe, David J
Format: Article en ligne
Langue:English
Publié: 2018
Accès à la collection:BioTechniques
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Palkovits micropunch metabolic imaging pathology-guided micropunching prostate tissue microenvironment tumor heterogeneity vital staining plus... Reactive Oxygen Species RNA 63231-63-0