|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM279554230 |
| 003 |
DE-627 |
| 005 |
20231225023235.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2018 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2017.12.008
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0931.xml
|
| 035 |
|
|
|a (DE-627)NLM279554230
|
| 035 |
|
|
|a (NLM)29292085
|
| 035 |
|
|
|a (PII)S1521-6616(17)30477-1
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Xuan, Jingxiu
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome
|
| 264 |
|
1 |
|c 2018
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 22.04.2019
|
| 500 |
|
|
|a Date Revised 07.12.2022
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2017. Published by Elsevier Inc.
|
| 520 |
|
|
|a In order to evaluate autoantibody to SP-1 as an early biomarker in pSS, we investigated autoantibody to SP-1 in Chinese patients with primary Sjögren's syndrome (pSS). Autoantibodies to SP-1 are significantly increased in pSS patients compared to RA patients, SLE patients, and healthy people without secondary SS. The presence of anti SP-1 antibodies was negatively correlated with the focus score (FS), RF, and salivary gland function. It was positively correlated with FS=0, RF≤20, and normal salivary gland function. In further studies, the autoantigen SP-1 was identified in ductal epithelia of salivary glands in il14α TG mice by IIF. SP-1 mRNAs expression increased with growing age in il14α TG mice. SP-1 mRNA was also identified in labial biopsies of patients with pSS. In conclusion, autoantibody to SP-1 is an early marker in pSS. It is useful to diagnose pSS patients who lack RF or antibodies to Ro/La
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Autoantibody to SP-1
|
| 650 |
|
4 |
|a Autoimmune, diagnosis
|
| 650 |
|
4 |
|a Biomarker
|
| 650 |
|
4 |
|a Primary Sjögren's syndrome
|
| 650 |
|
7 |
|a Autoantibodies
|2 NLM
|
| 650 |
|
7 |
|a Autoantigens
|2 NLM
|
| 650 |
|
7 |
|a Salivary Proteins and Peptides
|2 NLM
|
| 700 |
1 |
|
|a Wang, Ying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xiong, Yingling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Qian, Hongyan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a He, Yan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shi, Guixiu
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 188(2018) vom: 26. März, Seite 58-63
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:188
|g year:2018
|g day:26
|g month:03
|g pages:58-63
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2017.12.008
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 188
|j 2018
|b 26
|c 03
|h 58-63
|