Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome

Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome

Copyright © 2017. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 188(2018) vom: 26. März, Seite 58-63
1. Verfasser: Xuan, Jingxiu (VerfasserIn)
Weitere Verfasser: Wang, Ying, Xiong, Yingling, Qian, Hongyan, He, Yan, Shi, Guixiu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Autoantibody to SP-1 Autoimmune, diagnosis Biomarker Primary Sjögren's syndrome Autoantibodies Autoantigens Salivary Proteins and Peptides
Beschreibung
Zusammenfassung:Copyright © 2017. Published by Elsevier Inc.
In order to evaluate autoantibody to SP-1 as an early biomarker in pSS, we investigated autoantibody to SP-1 in Chinese patients with primary Sjögren's syndrome (pSS). Autoantibodies to SP-1 are significantly increased in pSS patients compared to RA patients, SLE patients, and healthy people without secondary SS. The presence of anti SP-1 antibodies was negatively correlated with the focus score (FS), RF, and salivary gland function. It was positively correlated with FS=0, RF≤20, and normal salivary gland function. In further studies, the autoantigen SP-1 was identified in ductal epithelia of salivary glands in il14α TG mice by IIF. SP-1 mRNAs expression increased with growing age in il14α TG mice. SP-1 mRNA was also identified in labial biopsies of patients with pSS. In conclusion, autoantibody to SP-1 is an early marker in pSS. It is useful to diagnose pSS patients who lack RF or antibodies to Ro/La
Beschreibung:Date Completed 22.04.2019
Date Revised 07.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2017.12.008