Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors

Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors

© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 218(2018), 1 vom: 30. Apr., Seite 183-200
1. Verfasser: Lung, Shiu-Cheung (VerfasserIn)
Weitere Verfasser: Liao, Pan, Yeung, Edward C, Hsiao, An-Shan, Xue, Yan, Chye, Mee-Len
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't GLABRA2 embryogenesis fatty acid lipid signaling protein interactor second messenger sterol trichome mehr... ACBP1 protein, Arabidopsis Arabidopsis Proteins Basic-Leucine Zipper Transcription Factors Carrier Proteins Fatty Acids Homeodomain Proteins Multiprotein Complexes Sterols AT4G22756 protein, Arabidopsis EC 1.- Mixed Function Oxygenases
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245 1 0 |a Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors 
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500 |a Date Revised 30.09.2020 
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520 |a © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust. 
520 |a Fatty acids (FAs) and sterols constitute building blocks of eukaryotic membranes and lipid signals. Co-regulation of FA and sterol synthesis is mediated by sterol regulatory element-binding proteins in animals but remains elusive in plants. We reported recently that Arabidopsis ACYL-COA-BINDING PROTEIN1 (ACBP1) modulates sterol synthesis via protein-protein interaction with STEROL C4-METHYL OXIDASE1-1 (SMO1-1). Herein, ACBP1 was demonstrated to co-express and interact with SMO1-2 by yeast two-hybrid, co-localization, pull-down, co-immunoprecipitation and β-glucuronidase assays. SMO1-2 silenced in acbp1 was used in phenotyping, GC-MS and expression profiling. ACBP1 co-expressed with SMO1-2 in embryo sacs, pollen and trichomes, corroborating with cooperative tissue-specific functions unseen with SMO1-1. SMO1-2 silencing in acbp1 impaired seed development, male and female gamete transmission, and pollen function. Genes encoding homeodomain-leucine zipper IV transcription factors (HDG5, HDG10, HDG11 and GLABRA2), which potentially bind phospholipids/sterols, were transcribed aberrantly. GLABRA2 targets (MYB23, MUM4 and PLDα1) were misregulated, causing glabra2-resembling trichome, seed coat mucilage and oil-accumulating phenotypes. Together with altered sterol and FA compositions upon ACBP1 mutation and/or SMO1-2 silencing, ACBP1-SMO1 interaction appears to mediate homeostatic co-regulation of FAs and sterols, which serve as lipid modulators for gene expression of homeodomain-leucine zipper IV transcription factors 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a GLABRA2 
650 4 |a embryogenesis 
650 4 |a fatty acid 
650 4 |a lipid signaling 
650 4 |a protein interactor 
650 4 |a second messenger 
650 4 |a sterol 
650 4 |a trichome 
650 7 |a ACBP1 protein, Arabidopsis  |2 NLM 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Basic-Leucine Zipper Transcription Factors  |2 NLM 
650 7 |a Carrier Proteins  |2 NLM 
650 7 |a Fatty Acids  |2 NLM 
650 7 |a Homeodomain Proteins  |2 NLM 
650 7 |a Multiprotein Complexes  |2 NLM 
650 7 |a Sterols  |2 NLM 
650 7 |a AT4G22756 protein, Arabidopsis  |2 NLM 
650 7 |a EC 1.-  |2 NLM 
650 7 |a Mixed Function Oxygenases  |2 NLM 
650 7 |a EC 1.-  |2 NLM 
700 1 |a Liao, Pan  |e verfasserin  |4 aut 
700 1 |a Yeung, Edward C  |e verfasserin  |4 aut 
700 1 |a Hsiao, An-Shan  |e verfasserin  |4 aut 
700 1 |a Xue, Yan  |e verfasserin  |4 aut 
700 1 |a Chye, Mee-Len  |e verfasserin  |4 aut 
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773 1 8 |g volume:218  |g year:2018  |g number:1  |g day:30  |g month:04  |g pages:183-200 
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