Synthesis of Fluorescent Au Nanocrystals-Silica Hybrid Nanocomposite (FLASH) with Enhanced Optical Features for Bioimaging and Photodynamic Activity

Synthesis of Fluorescent Au Nanocrystals-Silica Hybrid Nanocomposite (FLASH) with Enhanced Optical Features for Bioimaging and Photodynamic Activity

Fluorescent Au nanocrystals (AuNCs)-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. On the basis of these enh...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 34(2018), 1 vom: 09. Jan., Seite 173-178
1. Verfasser: Kim, Taeshik (VerfasserIn)
Weitere Verfasser: Jang, Hongje, Kim, Seongchan, Lee, Jong-Hwan, Kim, Sung-Yon, Jeon, Noo Li, Song, Joon Myong, Min, Dal-Hee
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antineoplastic Agents Benzimidazoles Fluorescent Dyes Photosensitizing Agents Silanes tetraethoxysilane 42064KRE49 Gold mehr... 7440-57-5 Silicon Dioxide 7631-86-9 Glutathione GAN16C9B8O bisbenzimide ethoxide trihydrochloride P976261J69 Methylene Blue T42P99266K
Beschreibung
Zusammenfassung:Fluorescent Au nanocrystals (AuNCs)-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. On the basis of these enhanced optical features, we successfully demonstrated in vitro fluorescence bioimaging of introduced FLASH to human cervical cancer cell line (HeLa). Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as a model compound, the regional selective photodynamic therapy of HeLa cells under UV irradiation was also presented. Taken together the enhanced optical features and further potential in theranostic applications, we expect that the present FLASH can be a promising tool for nanobiotechnology field
Beschreibung:Date Completed 11.09.2018
Date Revised 11.09.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1520-5827
DOI:10.1021/acs.langmuir.7b02562