Flyscan opportunities in medicine the case of quantum rattle based on gold quantum dots

Flyscan opportunities in medicine : the case of quantum rattle based on gold quantum dots

The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clini...

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Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 24(2017), Pt 5 vom: 01. Sept., Seite 991-999
1. Verfasser: Esteve, Emmanuel (VerfasserIn)
Weitere Verfasser: Reguer, Solenn, Boissiere, Cédric, Chanéac, Corinne, Lugo, Gustavo, Jouanneau, Chantal, Mocuta, Cristian, Thiaudière, Dominique, Leclercq, Nicolas, Leyh, Bernard, Greisch, Jean François, Berthault, Julien, Daudon, Michel, Ronco, Pierre, Bazin, Dominique
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article Flyscan method X-ray fluorescence XANES gold-cluster-enriched mesoporous silica nanospheres theranostic vectors
Beschreibung
Zusammenfassung:The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift. Moreover, numerous X-ray absorption near-edge structure spectra, which are beam-time-consuming taking into account the low concentration of these theranostic vectors, were collected
Beschreibung:Date Revised 20.11.2019
published: Print-Electronic
Citation Status PubMed-not-MEDLINE
ISSN:1600-5775
DOI:10.1107/S1600577517009572