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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201700448
|2 doi
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|a pubmed24n0911.xml
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hu, Yanyan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 22.01.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125 I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients
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|a Comparative Study
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|a Journal Article
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|a active targeting
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|a clinical intervention
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|a gold nanoshells
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|a interventional photothermal therapy
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|a pancreatic cancer
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|a Polyethylene Glycols
|2 NLM
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|a 3WJQ0SDW1A
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Indocyanine Green
|2 NLM
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|a IX6J1063HV
|2 NLM
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| 700 |
1 |
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|a Chi, Chongwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Shunhao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lingxiong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Fangyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shang, Wenting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Weiwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Fengrong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Shanshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Heyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Xiaoling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Huiyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Jie
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 33 vom: 28. Sept.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:29
|g year:2017
|g number:33
|g day:28
|g month:09
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|u http://dx.doi.org/10.1002/adma.201700448
|3 Volltext
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