A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 29(2017), 33 vom: 28. Sept.
1. Verfasser: Hu, Yanyan (VerfasserIn)
Weitere Verfasser: Chi, Chongwei, Wang, Shunhao, Wang, Lingxiong, Liang, Ping, Liu, Fangyi, Shang, Wenting, Wang, Weiwei, Zhang, Fengrong, Li, Shanshan, Shen, Heyun, Yu, Xiaoling, Liu, Huiyu, Tian, Jie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Comparative Study Journal Article active targeting clinical intervention gold nanoshells interventional photothermal therapy pancreatic cancer Polyethylene Glycols 3WJQ0SDW1A Gold mehr... 7440-57-5 Indocyanine Green IX6J1063HV
Beschreibung
Zusammenfassung:© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125 I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients
Beschreibung:Date Completed 22.01.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201700448