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231224s2018 xx |||||o 00| ||eng c |
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|a 10.1111/nph.14619
|2 doi
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|a pubmed24n0908.xml
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|a (DE-627)NLM272613843
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|a (NLM)28581033
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Dissmeyer, Nico
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Life and death of proteins after protease cleavage
|b protein degradation by the N-end rule pathway
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.10.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a CommentIn: New Phytol. 2018 May;218(3):879-881. - PMID 29658638
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|a Citation Status MEDLINE
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|a © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.
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|a Contents Summary 929 I
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|a INTRODUCTION: conservation and diversity of N-end rule pathways 929 II. Defensive functions of the N-end rule pathway in plants 930 III. Proteases and degradation by the N-end rule pathway 930 IV. New proteomics approaches for the identification of N-end rule substrates 932 V. Concluding remarks 932 Acknowledgements 934 References 934 SUMMARY: The N-end rule relates the stability of a protein to the identity of its N-terminal residue and some of its modifications. Since its discovery in the 1980s, the repertoire of N-terminal degradation signals has expanded, leading to a diversity of N-end rule pathways. Although some of these newly discovered N-end rule pathways remain largely unexplored in plants, recent discoveries have highlighted roles of N-end rule-mediated protein degradation in plant defense against pathogens and in cell proliferation during organ growth. Despite this progress, a bottleneck remains the proteome-wide identification of N-end rule substrates due to the prerequisite for endoproteolytic cleavage and technical limitations. Here, we discuss the recent diversification of N-end rule pathways and their newly discovered functions in plant defenses, stressing the role of proteases. We expect that novel proteomics techniques (N-terminomics) will be essential for substrate identification. We review these methods, their limitations and future developments
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a N-degron
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|a N-end rule pathway
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|a N-recognins
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|a N-terminomics
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|a arginylation
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|a cysteine oxidation
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|a proteases
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|a ubiquitin-proteasome system
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| 650 |
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Endopeptidases
|2 NLM
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| 650 |
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|a EC 3.4.-
|2 NLM
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| 700 |
1 |
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|a Rivas, Susana
|e verfasserin
|4 aut
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| 700 |
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|a Graciet, Emmanuelle
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 218(2018), 3 vom: 24. Mai, Seite 929-935
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
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|g volume:218
|g year:2018
|g number:3
|g day:24
|g month:05
|g pages:929-935
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|u http://dx.doi.org/10.1111/nph.14619
|3 Volltext
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|d 218
|j 2018
|e 3
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|h 929-935
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