Life and death of proteins after protease cleavage protein degradation by the N-end rule pathway

Life and death of proteins after protease cleavage : protein degradation by the N-end rule pathway

© 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 218(2018), 3 vom: 24. Mai, Seite 929-935
1. Verfasser: Dissmeyer, Nico (VerfasserIn)
Weitere Verfasser: Rivas, Susana, Graciet, Emmanuelle
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Review N-degron N-end rule pathway N-recognins N-terminomics arginylation cysteine oxidation proteases mehr... ubiquitin-proteasome system Plant Proteins Endopeptidases EC 3.4.-
Beschreibung
Zusammenfassung:© 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.
Contents Summary 929 I
INTRODUCTION: conservation and diversity of N-end rule pathways 929 II. Defensive functions of the N-end rule pathway in plants 930 III. Proteases and degradation by the N-end rule pathway 930 IV. New proteomics approaches for the identification of N-end rule substrates 932 V. Concluding remarks 932 Acknowledgements 934 References 934 SUMMARY: The N-end rule relates the stability of a protein to the identity of its N-terminal residue and some of its modifications. Since its discovery in the 1980s, the repertoire of N-terminal degradation signals has expanded, leading to a diversity of N-end rule pathways. Although some of these newly discovered N-end rule pathways remain largely unexplored in plants, recent discoveries have highlighted roles of N-end rule-mediated protein degradation in plant defense against pathogens and in cell proliferation during organ growth. Despite this progress, a bottleneck remains the proteome-wide identification of N-end rule substrates due to the prerequisite for endoproteolytic cleavage and technical limitations. Here, we discuss the recent diversification of N-end rule pathways and their newly discovered functions in plant defenses, stressing the role of proteases. We expect that novel proteomics techniques (N-terminomics) will be essential for substrate identification. We review these methods, their limitations and future developments
Beschreibung:Date Completed 01.10.2019
Date Revised 30.09.2020
published: Print-Electronic
CommentIn: New Phytol. 2018 May;218(3):879-881. - PMID 29658638
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.14619