Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms asso...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Neural plasticity. - 1998. - 2017(2017) vom: 11., Seite 4135164
1. Verfasser: Jiang, Huili (VerfasserIn)
Weitere Verfasser: Zhang, Xuhui, Wang, Yu, Zhang, Huimin, Li, Jing, Yang, Xinjing, Zhao, Bingcong, Zhang, Chuntao, Yu, Miao, Xu, Mingmin, Yu, Qiuyun, Liang, Xingchen, Li, Xiang, Shi, Peng, Bao, Tuya
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Neural plasticity
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antidepressive Agents, Second-Generation Cyclic AMP Response Element-Binding Protein Isoquinolines Protein Kinase Inhibitors Sulfonamides Fluoxetine 01K63SUP8D Cyclic AMP-Dependent Protein Kinases mehr... EC 2.7.11.11 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide M876330O56
LEADER 01000caa a22002652 4500
001 NLM272059129
003 DE-627
005 20250221162643.0
007 cr uuu---uuuuu
008 231224s2017 xx |||||o 00| ||eng c
024 7 |a 10.1155/2017/4135164  |2 doi 
028 5 2 |a pubmed25n0906.xml 
035 |a (DE-627)NLM272059129 
035 |a (NLM)28523193 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Jiang, Huili  |e verfasserin  |4 aut 
245 1 0 |a Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway 
264 1 |c 2017 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 12.03.2018 
500 |a Date Revised 31.03.2022 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms associated with antidepressant response of acupuncture, neurogenesis, and depressive-like behaviors ameliorating remain unexplored. The objective was to identify the mechanisms underlying the antidepressant response of acupuncture through PKA signaling pathway in depression rats by employing the PKA signaling pathway inhibitor H89 in in vivo experiments. Our results indicated that the expression of hippocampal PKA-α and p-CREB was significantly downregulated by chronic unpredicted mild stress (CUMS) procedures. Importantly, acupuncture reversed the downregulation of PKA-α and p-CREB. The expression of PKA-α was upregulated by fluoxetine, but not p-CREB. No significant difference was found between Acu and FLX groups on the expression of PKA-α and p-CREB. Interestingly, H89 inhibited the effects of acupuncture or fluoxetine on upregulating the expression of p-CREB, but not PKA-α. There was no significant difference in expression of CREB among the groups. Conclusively, our findings further support the hypothesis that acupuncture could ameliorate depressive-like behaviors by regulating PKA/CREB signaling pathway, which might be mainly mediated by regulating the phosphorylation level of CREB 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Antidepressive Agents, Second-Generation  |2 NLM 
650 7 |a Cyclic AMP Response Element-Binding Protein  |2 NLM 
650 7 |a Isoquinolines  |2 NLM 
650 7 |a Protein Kinase Inhibitors  |2 NLM 
650 7 |a Sulfonamides  |2 NLM 
650 7 |a Fluoxetine  |2 NLM 
650 7 |a 01K63SUP8D  |2 NLM 
650 7 |a Cyclic AMP-Dependent Protein Kinases  |2 NLM 
650 7 |a EC 2.7.11.11  |2 NLM 
650 7 |a N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide  |2 NLM 
650 7 |a M876330O56  |2 NLM 
700 1 |a Zhang, Xuhui  |e verfasserin  |4 aut 
700 1 |a Wang, Yu  |e verfasserin  |4 aut 
700 1 |a Zhang, Huimin  |e verfasserin  |4 aut 
700 1 |a Li, Jing  |e verfasserin  |4 aut 
700 1 |a Yang, Xinjing  |e verfasserin  |4 aut 
700 1 |a Zhao, Bingcong  |e verfasserin  |4 aut 
700 1 |a Zhang, Chuntao  |e verfasserin  |4 aut 
700 1 |a Yu, Miao  |e verfasserin  |4 aut 
700 1 |a Xu, Mingmin  |e verfasserin  |4 aut 
700 1 |a Yu, Qiuyun  |e verfasserin  |4 aut 
700 1 |a Liang, Xingchen  |e verfasserin  |4 aut 
700 1 |a Li, Xiang  |e verfasserin  |4 aut 
700 1 |a Shi, Peng  |e verfasserin  |4 aut 
700 1 |a Bao, Tuya  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Neural plasticity  |d 1998  |g 2017(2017) vom: 11., Seite 4135164  |w (DE-627)NLM098558390  |x 1687-5443  |7 nnns 
773 1 8 |g volume:2017  |g year:2017  |g day:11  |g pages:4135164 
856 4 0 |u http://dx.doi.org/10.1155/2017/4135164  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_21 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 2017  |j 2017  |b 11  |h 4135164