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20231224225902.0 |
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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.03.006
|2 doi
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|a pubmed24n0900.xml
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|a (NLM)28323147
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|a (PII)S1521-6616(16)30521-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a de Melo, Karina Mescouto
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Increase of circulating α4β7+ conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID)
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.08.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a This study investigated whether circulating α4β7+ expressing T cells could serve as a potential marker for gastrointestinal (GI) disease activity in patients with CVID. The analysis of α4β7+ T cells in the peripheral blood of 36 patients and 22 healthy donors (HD) revealed increased percentages of α4β7+ conventional memory CD4 T cells and Tregs, but not among CD8 T-cell populations in patients with CVID compared to HD. No differences between patients with and without chronic or acute GI symptoms were observed. EUROClass smB- and 21lo patients, had higher percentages of α4β7+ memory CD4 T cells compared to HD and smB+ or 21norm patients, respectively. In summary, the detection of α4β7+ T cells in the peripheral blood did not correlate with active or chronic gastrointestinal disease. The increase of these cells in smB- and 21lo patients adds another piece to the immune dysregulation observed in these patients
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| 650 |
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Common variable immunodeficiency
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| 650 |
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|a Diagnostics
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| 650 |
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4 |
|a Enteropathy
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| 650 |
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|a Homing
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| 650 |
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4 |
|a T cell
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| 650 |
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4 |
|a α4β7
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| 650 |
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7 |
|a Integrins
|2 NLM
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| 650 |
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7 |
|a integrin alpha4beta7
|2 NLM
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| 700 |
1 |
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|a Unger, Susanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Keller, Baerbel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gutenberger, Sylvia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stumpf, Ina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Goldacker, Sigune
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Warnatz, Klaus
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 180(2017) vom: 01. Juli, Seite 80-83
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:180
|g year:2017
|g day:01
|g month:07
|g pages:80-83
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.03.006
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