Enhanced Performance of Blended Polymer Excipients in Delivering a Hydrophobic Drug through the Synergistic Action of Micelles and HPMCAS
Blends of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and dodecyl (C12)-tailed poly(N-isopropylacrylamide) (PNIPAm) were systematically explored as a model system to dispense the active ingredient phenytoin by rapid dissolution, followed by the suppression of drug crystallization for an...
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Bibliographische Detailangaben
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 33(2017), 11 vom: 21. März, Seite 2837-2848
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| 1. Verfasser: |
Li, Ziang
(VerfasserIn) |
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| Weitere Verfasser: |
Johnson, Lindsay M,
Ricarte, Ralm G,
Yao, Letitia J,
Hillmyer, Marc A,
Bates, Frank S,
Lodge, Timothy P |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2017
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Acrylamides
Acrylic Resins
Excipients
Micelles
Polymers
poly-N-isopropylacrylamide
25189-55-3
mehr...
Phenytoin
6158TKW0C5
hydroxypropylmethylcellulose acetate succinate
71138-97-1
Methylcellulose
9004-67-5
N-isopropylacrylamide
B7GFF17L9U |
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